心肌梗塞
心功能曲线
心脏病学
医学
活性氧
内科学
心力衰竭
化学
生物化学
作者
Yue Guan,Hong Niu,Jiaxing Wen,Yu Dang,Mohamed A. Zayed,Jianjun Guan
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-11-11
卷期号:16 (11): 19551-19566
被引量:25
标识
DOI:10.1021/acsnano.2c10043
摘要
Myocardial infarction (MI) causes massive cell death due to restricted blood flow and oxygen deficiency. Rapid and sustained oxygen delivery following MI rescues cardiac cells and restores cardiac function. However, current oxygen-generating materials cannot be administered during acute MI stage without direct injection or suturing methods, both of which risk rupturing weakened heart tissue. Here, we present infarcted heart-targeting, oxygen-releasing nanoparticles capable of being delivered by intravenous injection at acute MI stage, and specifically accumulating in the infarcted heart. The nanoparticles can also be delivered before MI, then gather at the injured area after MI. We demonstrate that the nanoparticles, delivered either pre-MI or post-MI, enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. Our findings demonstrate that oxygen-delivering nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.
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