化学
体内
成纤维细胞生长因子受体4
肝细胞癌
FGF19型
药理学
生物化学
癌症研究
受体
成纤维细胞生长因子
成纤维细胞生长因子受体
医学
生物
生物技术
作者
Fang Yang,Qianmeng Lin,Xiaojuan Song,Huisi Huang,Xiaojuan Chen,Jianwen Tan,Yun Li,Yang Zhou,Zhengchao Tu,Hongli Du,Zhimin Zhang,Raquel Ortega,Xiaojing Lin,Adam V. Patterson,Jeff B. Smaill,Yongheng Chen,Xiaoyun Lu
标识
DOI：10.1021/acs.jmedchem.3c01810
摘要
Fibroblast growth factor receptor 4 (FGFR4) has been considered as a potential anticancer target due to FGF19/FGFR4 mediated aberrant signaling in hepatocellular carcinoma (HCC). Several FGFR4 inhibitors have been reported, but none have gained approval. Herein, a series of 5-formyl-pyrrolo[3,2-
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