光热治疗
肿瘤微环境
化学
癌细胞
生物物理学
纳米技术
材料科学
癌症研究
癌症
医学
生物
内科学
肿瘤细胞
作者
Fanqi Liu,Chang Guo,Xindi Li,Yumin Li,Suying Xu,Tony D. James,Leyu Wang
出处
期刊:Nano Today
[Elsevier]
日期:2023-12-27
卷期号:54: 102116-102116
被引量:10
标识
DOI:10.1016/j.nantod.2023.102116
摘要
A stepwise morphologic transformation is highly desirable but rarely reported for promoting drug penetration at tumor sites via reducing transport barriers. Herein, an adhesive multifunctional nano-transformer (CTMF NPs) with cascading structural transformation was constructed, which afforded tumor microenvironment (TME)-activatable zero-background 19F-magnetic resonance imaging and ratiometric photoacoustic imaging-guided synergistic tumor therapy. CTMF NPs were synthesized via a one-pot encapsulation and dynamic coordination strategy, where copper sulfide nanoparticles (CuS NPs, photothermal agent) were co-encapsulated with perfluoro-15-crown-5-ether (PFCE, 19F MRI agent) by the dopamine grafted amphiphilic polymer, followed by coating with metal (Mn2+)-polyphenol shell (19F signal quencher and therapeutic agent). Benefiting from polyphenol enhanced cell adherence as well as in situ generated reactive quinone, the CTMF NPs attached to tumor sites and exhibited efficient internalization under TME promoted decomposition and oxidation. Moreover, these nano-platforms were further decomposed under laser irradiation, which amplified cellular oxidative stress, leading to mitochondrial structural damage and dysfunction, as well as facilitating cuproptosis by interfering with the lipoylated tricarboxylic acid cycle. Cell apoptosis subsequently resulted in significant immunogenic cell death and afforded a versatile nano-transformer for precise imaging-guided bladder cancer therapy.
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