Catalyst-free nucleophilic substitution of hydrogen in quinoline rings by acylethynylpyrroles: stereoselective synthesis of 2-(E-2-acylethenylpyrrolyl)quinolines

A new type of S N H Ar reaction in the quinoline core under the action of available acylethynylpyrroles proceeds without halogenated reagents and any catalysts to stereoselectively afford 2-( E -2-acylethenylpyrrolyl)quinolines with a yield up to 78%.