亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Association between a deep learning-based scoring system with morphokinetics and morphological alterations in human embryos

卵裂球 胚泡 原核 胚胎 男科 生物 人类受精 胚胎移植 胚胎发生 合子 解剖 医学 遗传学
作者
Kenji Ezoe,Kiyoe Shimazaki,Tetsuya Miki,Tsubasa Takahashi,Yuko Tanimura,Ayumi Amagai,Ayano Sawado,Hikari Akaike,Mai Mogi,S Kaneko,Tadashi Okimura,Keiichi Kato
出处
期刊:Reproductive Biomedicine Online [Elsevier]
卷期号:45 (6): 1124-1132 被引量:6
标识
DOI:10.1016/j.rbmo.2022.08.098
摘要

What is the association between the deep learning-based scoring system, iDAScore, and biological events during the pre-implantation period?Retrospective observational study of patients (n = 925) who underwent oocyte retrieval in a clomiphene citrate-based minimal stimulation cycle and obtained expanded blastocysts between October 2019 and December 2020. The association between iDAScore with morphokinetics and morphological alteration during fertilization, cleavage stage, compaction and blastocyst stage was analysed.The duration of the cytoplasmic halo was significantly prolonged in low-scoring blastocysts (P < 0.0001). The timing of female and male pronuclei breakdown was significantly delayed in low-scoring blastocysts compared with high-scoring blastocysts (P < 0.0001 in both). Embryos with either trichotomous, multi-chotomous, rapid or reverse cleavage or asymmetric division had a lower score than embryos with normal cleavage (P < 0.0001-0.0098). The cell number and amount of blastomere fragmentation on days 2 and 3 were significantly associated with iDAScore (P < 0.0001-0.0008). Delayed compaction, blastulation and blastocyst expansion were observed in low-scoring embryos (P < 0.0001 in all). The incidence of blastomere exclusion and extrusion during embryonic compaction was significantly higher in low-scoring embryos than in high-scoring embryos (P ≤ 0.0001 in both). Blastocyst morphology was significantly associated with iDAScore (P < 0.0001). Multiple linear regression analysis revealed that, during the transformation to blastocyst stage, morphokinetic and morphological events were strongly associated with iDAScore (P < 0.0001-0.0116).iDAScore was significantly correlated with morphokinetics and morphological alterations of pre-implantation embryos, especially during the late pre-implantation period. Our findings contribute to research on deep learning model-based embryo selection, which may provide patients with a compelling explanation of blastocyst selection.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小奋青完成签到 ,获得积分10
56秒前
科研通AI2S应助欻欻采纳,获得10
1分钟前
John完成签到,获得积分10
2分钟前
行隐应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助spark810采纳,获得10
3分钟前
Kabutack完成签到,获得积分10
3分钟前
谢小盟完成签到 ,获得积分10
4分钟前
fendy完成签到,获得积分0
4分钟前
33应助闪闪飞阳采纳,获得20
4分钟前
5分钟前
耍酷秋完成签到,获得积分10
5分钟前
SciGPT应助耍酷秋采纳,获得10
6分钟前
闪闪飞阳完成签到,获得积分10
6分钟前
6分钟前
实力不允许完成签到 ,获得积分10
6分钟前
史前巨怪完成签到,获得积分10
6分钟前
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
6分钟前
猪皮恶人发布了新的文献求助10
6分钟前
呆呆完成签到 ,获得积分10
6分钟前
7分钟前
春风完成签到 ,获得积分10
9分钟前
bernice完成签到,获得积分10
9分钟前
10分钟前
10分钟前
drz完成签到 ,获得积分10
10分钟前
图样图森破完成签到,获得积分10
11分钟前
小白完成签到 ,获得积分10
11分钟前
13分钟前
Leo完成签到 ,获得积分10
13分钟前
14分钟前
耍酷秋发布了新的文献求助10
14分钟前
茶茶完成签到,获得积分10
14分钟前
15分钟前
iShine完成签到 ,获得积分10
15分钟前
欻欻发布了新的文献求助10
16分钟前
爱笑的眼睛完成签到,获得积分10
16分钟前
充电宝应助科研通管家采纳,获得10
16分钟前
jyy发布了新的文献求助200
16分钟前
高分求助中
Sustainability in Tides Chemistry 2000
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
Дружба 友好报 (1957-1958) 1000
Diamonds: Properties, Synthesis and Applications 1000
The Data Economy: Tools and Applications 1000
Mantiden - Faszinierende Lauerjäger – Buch gebraucht kaufen 700
PraxisRatgeber Mantiden., faszinierende Lauerjäger. – Buch gebraucht kaufe 700
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3099758
求助须知:如何正确求助?哪些是违规求助? 2751215
关于积分的说明 7612024
捐赠科研通 2403006
什么是DOI,文献DOI怎么找? 1275089
科研通“疑难数据库(出版商)”最低求助积分说明 616238
版权声明 599033