Does OSA Increase Risk for Cancer?

医学 肺癌 癌症 危险系数 低氧血症 入射(几何) 体质指数 内科学 人口学 置信区间 光学 物理 社会学
作者
Ross J. Marriott,Bhajan Singh,Nigel McArdle,Ellie Darcey,Stuart King,Daniela Bond‐Smith,A Reynor,William Noffsinger,Kim Ward,Sutapa Mukherjee,David R. Hillman,Gemma Cadby
出处
期刊:Chest [Elsevier BV]
卷期号:164 (4): 1042-1056 被引量:5
标识
DOI:10.1016/j.chest.2023.04.043
摘要

The relationship between OSA and cancer is unclear.What is the association between OSA and cancer prevalence and incidence in a large Western Australian sleep clinic cohort (N = 20,289)?OSA severity was defined by apnea-hypopnea index (AHI) and nocturnal hypoxemia (duration and percentage at oxygen saturation < 90%) measured by in-laboratory polysomnogram. Measures of potential confounding included age, sex, BMI, smoking status, socioeconomic status, and BP. Outcomes were determined from the Western Australian cancer and death registries. Analyses were confined within periods using consistent AHI scoring criteria: January 1, 1989, to July 31, 2002 (American Sleep Disorders Association criteria), and August 1, 2002, to June 30, 2013 (Chicago criteria). We examined associations of AHI and nocturnal hypoxemia with cancer prevalence using logistic regression and cancer incidence using Cox regression analyses.Cancer prevalence at baseline was 329 of 10,561 in the American Sleep Disorders Association period and 633 of 9,728 in the Chicago period. Nocturnal hypoxemia but not AHI was independently associated with prevalent cancer following adjustment for participant age, sex, BMI, smoking status, socioeconomic status, and BP. Of those without prevalent cancer, cancer was diagnosed in 1,950 of 10,232 (American Sleep Disorders Association) and 623 of 9,095 (Chicago) participants over a median follow-up of 11.2 years. Compared with the reference category (no OSA, AHI < 5 events per hour), univariable models estimated higher hazard ratios for cancer incidence for mild (AHI 5-15 events per hour), moderate (AHI 15.1-30 events per hour), and severe (AHI > 30 events per hour) OSA. Multivariable analyses consistently revealed associations between age and, in some cases, sex, BMI, and smoking status, with cancer incidence. After adjusting for confounders, multivariable models showed no independent association between OSA severity and increased cancer incidence.Nocturnal hypoxemia is independently associated with prevalent cancer. OSA severity is associated with incident cancer, although this association seems secondary to other risk factors for cancer development. OSA is not an independent risk factor for cancer incidence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助海德堡采纳,获得10
1秒前
iNk应助狂野的迎波采纳,获得10
1秒前
Qiao完成签到 ,获得积分10
2秒前
2秒前
ly完成签到,获得积分20
4秒前
科yt完成签到,获得积分10
4秒前
6秒前
iNk应助科研助力采纳,获得10
6秒前
自有龙骧完成签到 ,获得积分10
7秒前
ho完成签到 ,获得积分10
8秒前
9秒前
CipherSage应助科研通管家采纳,获得10
9秒前
华仔应助科研通管家采纳,获得10
9秒前
搜集达人应助科研通管家采纳,获得10
9秒前
wanci应助科研通管家采纳,获得10
9秒前
CodeCraft应助科研通管家采纳,获得10
9秒前
小蘑菇应助科研通管家采纳,获得10
9秒前
caffeine应助科研通管家采纳,获得10
9秒前
9秒前
思源应助科研通管家采纳,获得10
9秒前
SciGPT应助科研通管家采纳,获得10
10秒前
万能图书馆应助狂野白梅采纳,获得10
10秒前
SciGPT应助科研通管家采纳,获得10
10秒前
所所应助科研通管家采纳,获得10
10秒前
Hello应助科研通管家采纳,获得10
10秒前
领导范儿应助科研通管家采纳,获得10
10秒前
星辰大海应助科研通管家采纳,获得10
10秒前
顾矜应助科研通管家采纳,获得10
10秒前
脑洞疼应助科研通管家采纳,获得10
10秒前
深情安青应助科研通管家采纳,获得10
11秒前
领导范儿应助科研通管家采纳,获得10
11秒前
CAOHOU应助科研通管家采纳,获得10
11秒前
科目三应助科研通管家采纳,获得10
11秒前
科目三应助科研通管家采纳,获得10
11秒前
11秒前
开心蘑菇应助科研通管家采纳,获得10
11秒前
英俊的铭应助科研通管家采纳,获得10
11秒前
英俊的铭应助科研通管家采纳,获得10
11秒前
11秒前
天天快乐应助科研通管家采纳,获得20
11秒前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
Indomethacinのヒトにおける経皮吸収 400
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 370
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3991418
求助须知:如何正确求助?哪些是违规求助? 3532704
关于积分的说明 11258583
捐赠科研通 3271719
什么是DOI,文献DOI怎么找? 1805512
邀请新用户注册赠送积分活动 882545
科研通“疑难数据库(出版商)”最低求助积分说明 809325