神经炎症
化学
乙酰胆碱
药理学
阿尔茨海默病
胆碱酯酶
疾病
丁酰胆碱酯酶
神经科学
乙酰胆碱酯酶
阿切
生物化学
内科学
酶
心理学
医学
作者
Ying Chen,Weiting Zhang,Qi Li,Huanfang Xie,Shuaishuai Xing,Xin Lü,Weiping Lyu,Baichen Xiong,Yuanyuan Wang,Wei Qu,Wenyuan Liu,Heng Chi,Xiaolong Zhang,Feng Feng,Haopeng Sun
标识
DOI：10.1016/j.ejmech.2024.116463
摘要
Butyrylcholinesterase (BChE) has attracted wide interest as a promising target in Alzheimer's disease (AD) investigation. BChE is considered to play a compensable role of hydrolyzing acetylcholine (ACh), and its positive correlation with β-amyloid (Aβ) deposition also promotes disease progression. Herein, we uncovered a selective potent BChE inhibitor S21-1011 (eqBChE IC
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