化学
天然产物
血管生成
抗癌药
天然化合物
药品
癌症研究
药理学
立体化学
生物
生化工程
工程类
作者
Ziqing Zhang,Meng Xu,Ruling Shi,Xinyi He,Li Wang,Yongying Shao,Caixia Huang,Feng‐Yang Zhang,Peixi Zhang,Jie‐Qing Liu
标识
DOI：10.1002/cbdv.202400753
摘要
VEGFR-2 is a prominent therapeutic target in antitumor drug research to block tumor angiogenesis. This study focused on the synthesis and optimization of PROTACs based on the natural product rhein, resulting in the successful synthesis of 15 distinct molecules. In A549 cells, D9 exhibited remarkable antitumor efficacy with an IC
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