PIPAC in patients with peritoneal metastases from gastrointestinal tract (PIPOX01): an open label, non-comparative phase 1/2 dose escalation and expansion trial.

Despite modern systemic chemotherapy, survival remains poor for patients with advanced isolated peritoneal metastases from the gastrointestinal tract. We aimed to assess the safety and efficacy of pressurized intraperitoneal aerosol chemotherapy (PIPAC) with oxaliplatin.