人巨细胞病毒
巨细胞病毒
病毒学
病毒
抗病毒药物
抗病毒治疗
免疫学
生物
病毒潜伏期
医学
疱疹病毒科
病毒复制
病毒性疾病
慢性肝炎
作者
Kingshuk Panda,Deepti Parashar,Rajlakshmi Viswanathan
出处
期刊:Viruses
[MDPI AG]
日期:2023-06-12
卷期号:15 (6): 1358-1358
被引量:11
摘要
Human cytomegalovirus (HCMV) remains an essential global concern due to its distinct life cycle, mutations and latency. As HCMV is a herpesvirus, it establishes a lifelong persistence in the host through a chronic state of infection. Immunocompromised individuals are at risk of significant morbidity and mortality from the virus. Until now, no effective vaccine has been developed to combat HCMV infection. Only a few antivirals targeting the different stages of the virus lifecycle and viral enzymes are licensed to manage the infection. Therefore, there is an urgent need to find alternate strategies to combat the infection and manage drug resistance. This review will provide an insight into the clinical and preclinical antiviral approaches, including HCMV antiviral drugs and nucleic acid-based therapeutics.
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