Hepatocellular carcinoma surveillance may be associated with potential psychological harms in patients with cirrhosis

焦虑 医学 后悔 临床心理学 不确定 内科学 担心 肝硬化 苦恼 精神科 纯数学 数学 机器学习 计算机科学
作者
Manasa Narasimman,Rubén Hernáez,Vanessa Cerda,MinJae Lee,Anubha Sood,Sruthi Yekkaluri,Aisha Khan,Lisa Quirk,Yan Liu,Jennifer R. Kramer,Simon J. Craddock Lee,Caitlin C. Murphy,Jasmin A. Tiro,Amit G. Singal
出处
期刊:Hepatology [Lippincott Williams & Wilkins]
卷期号:79 (1): 107-117 被引量:40
标识
DOI:10.1097/hep.0000000000000528
摘要

Background and Aims: The value of HCC surveillance is determined by the balance between benefits and harms; however, no studies have enumerated psychological harms. Approach and Results: We fielded surveys measuring psychological harms to patients with cirrhosis in a multicenter randomized trial of HCC surveillance outreach. All patients with positive or indeterminate surveillance results and matched patients with negative results were invited to complete surveys measuring (1) depression through the Patient Health Questionnaire-ninth version, (2) anxiety through State-Trait Anxiety Inventory, (3) HCC-specific worry through Psychological Consequences Questionnaire, and (4) decisional regret. Patients were classified into 4 groups: true positive (TP), false positive (FP), indeterminate, and true negative (TN). Multivariable longitudinal regression analysis using the generalized estimating equation method was performed to compare the means of measures across groups. We conducted 89 semistructured interviews in a subset of patients stratified by health system and test results. Of 2872 patients in the trial, 311 completed 1+ follow-up survey (63 FP, 77 indeterminate, 38 TP, and 133 TN). Moderate depression decreased in TN patients, increased in TP, and had intermittent but mild increases in those with FP and indeterminate results. High anxiety temporarily increased in patients with TP results but resolved over time and was stable in those with FP and indeterminate results. Decisional regret was low and did not differ across groups. In semistructured interviews, patients reported apprehension, anxiety, emotional distress, and coping related to HCC surveillance. Conclusions: Psychological harms of HCC surveillance appear mild but differ by test result. Future research should determine the impact of psychological harms on the value of HCC surveillance programs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
小饼干完成签到,获得积分10
1秒前
白白SAMA123完成签到,获得积分10
2秒前
蒲公英发布了新的文献求助10
2秒前
梦想里发布了新的文献求助10
4秒前
执剑燃此生完成签到,获得积分10
5秒前
5秒前
shinn发布了新的文献求助10
6秒前
6秒前
7秒前
7秒前
楚舜华发布了新的文献求助10
7秒前
7秒前
8秒前
练习时长两年半应助variant采纳,获得10
9秒前
打打应助刘潮汕采纳,获得10
10秒前
10秒前
wjx发布了新的文献求助30
10秒前
二零发布了新的文献求助10
10秒前
共享精神应助Jian采纳,获得10
10秒前
11秒前
周杰伦发布了新的文献求助10
11秒前
NINI完成签到,获得积分10
12秒前
wangerer发布了新的文献求助30
12秒前
小饼干发布了新的文献求助10
12秒前
13秒前
13秒前
梦想里完成签到,获得积分10
14秒前
朽木发布了新的文献求助10
14秒前
hh发布了新的文献求助10
14秒前
隐形曼青应助科研通管家采纳,获得10
14秒前
15秒前
彭于晏应助科研通管家采纳,获得10
15秒前
yar应助科研通管家采纳,获得10
15秒前
15秒前
15秒前
15秒前
领导范儿应助科研通管家采纳,获得10
15秒前
15秒前
wanci应助二零采纳,获得10
16秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975165
求助须知:如何正确求助?哪些是违规求助? 3519595
关于积分的说明 11198781
捐赠科研通 3255912
什么是DOI,文献DOI怎么找? 1798001
邀请新用户注册赠送积分活动 877343
科研通“疑难数据库(出版商)”最低求助积分说明 806298