挤压
研磨
产量(工程)
薯条重组
球磨机
塑料挤出
炸薯条
球(数学)
材料科学
化学工程
化学
有机化学
冶金
数学
催化作用
几何学
食品科学
工程类
作者
Daniel M. Baier,Tilo Rensch,Konrad Bergheim,Viktoria Pietryga,Sven Grätz,Lars Borchardt
标识
DOI:10.1002/chem.202203931
摘要
Herein, the first mechanochemical Fries rearrangement for the industrially important synthesis of para-hydroxyacetophenone, inside a ball mill and a twin-screw extruder, is presented. Our approach leads to a yield of 62 % in as little as 90 minutes while liquid-assisted grinding can shift the isomer ratio resulting in an excess of the desired para-product. The multigram scale-up by extrusion leads to 61 % yield in only three minutes while completely avoiding solvents. The extrusion temperature can even further be reduced by combining extrusion with a subsequent ageing step.
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