A novel FUS::NFATC4 fusion detected in a sarcoma with morphological features overlapping with NFATC2 sarcomas

HistopathologyEarly View Correspondence A novel FUS::NFATC4 fusion detected in a sarcoma with morphological features overlapping with NFATC2 sarcomas Natálie Klubíčková, Corresponding Author Natálie Klubíčková [email protected] orcid.org/0000-0002-4407-5544 Bioptical Laboratory Ltd., Plzen, Czech Republic Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech Republic Address for correspondence: Natálie Klubíčková MD, Department of Pathology, Medical Faculty and University Hospital Plzen, Charles University, Alej Svobody 80 323 00, Pilsen, Czech Republic. e-mail: [email protected] cellular phone: +420737220749Search for more papers by this authorJohn M Gross, John M Gross orcid.org/0000-0003-4444-0297 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USASearch for more papers by this authorKateřina Comová, Kateřina Comová Bioptical Laboratory Ltd., Plzen, Czech RepublicSearch for more papers by this authorJozef Kuruc, Jozef Kuruc orcid.org/0000-0002-5772-3969 Cytopathos Ltd., Bratislava, SlovakiaSearch for more papers by this authorMichael Michal, Michael Michal orcid.org/0000-0003-4403-7027 Bioptical Laboratory Ltd., Plzen, Czech Republic Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech RepublicSearch for more papers by this author Natálie Klubíčková, Corresponding Author Natálie Klubíčková [email protected] orcid.org/0000-0002-4407-5544 Bioptical Laboratory Ltd., Plzen, Czech Republic Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech Republic Address for correspondence: Natálie Klubíčková MD, Department of Pathology, Medical Faculty and University Hospital Plzen, Charles University, Alej Svobody 80 323 00, Pilsen, Czech Republic. e-mail: [email protected] cellular phone: +420737220749Search for more papers by this authorJohn M Gross, John M Gross orcid.org/0000-0003-4444-0297 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USASearch for more papers by this authorKateřina Comová, Kateřina Comová Bioptical Laboratory Ltd., Plzen, Czech RepublicSearch for more papers by this authorJozef Kuruc, Jozef Kuruc orcid.org/0000-0002-5772-3969 Cytopathos Ltd., Bratislava, SlovakiaSearch for more papers by this authorMichael Michal, Michael Michal orcid.org/0000-0003-4403-7027 Bioptical Laboratory Ltd., Plzen, Czech Republic Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech RepublicSearch for more papers by this author First published: 09 October 2023 https://doi.org/10.1111/his.15066Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Kallen ME, Hornick JL. The 2020 WHO classification: what's new in soft tissue tumor pathology? Am. J. Surg. Pathol. 2021; 45; e1–e23. 2Michal M, Rubin BP, Agaimy A et al. EWSR1-PATZ1-rearranged sarcoma: a report of nine cases of spindle and round cell neoplasms with predilection for thoracoabdominal soft tissues and frequent expression of neural and skeletal muscle markers. Mod. Pathol. 2021; 34; 770–785. 3Perret R, Escuriol J, Velasco V et al. NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker. Mod. Pathol. 2020; 33; 1930–1944. 4Torres-Mora J, Fritchie K, Folpe AL et al. Soft tissue and bone tumors with EWSR1/FUS::NFATC2 gene fusions: a clinico-pathologic study of 28 cases emphasizing their broad morphologic spectrum. Lab. Invest. 2023; 103; S72. 5Wang GY, Thomas DG, Davis JL et al. EWSR1-NFATC2 translocation-associated sarcoma clinicopathologic findings in a rare aggressive primary bone or soft tissue tumor. Am. J. Surg. Pathol. 2019; 43; 1112–1122. 6 Genecards—the human gene database (database online). NFATC4 gene. 2023. Available at: https://www.genecards.org/cgi-bin/carddisp.pl?gene=NFATC4#paralogs. 7Zhong Q-H, Zha S-W, Lau ATY, Xu Y-M. Recent knowledge of NFATc4 in oncogenesis and cancer prognosis. Cancer Cell Int. 2022; 22; 212. Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation