Acute and 90-day toxicological safety assessment of Shang-Ke-Huang-Shui lotion in New Zealand White rabbits

急性毒性 医学 毒性 洗剂 传统医学 中医药 药理学 刺激 皮肤刺激 皮肤病科 内科学 病理 替代医学 免疫学
作者
Fanghao Zheng,Tingting Zhao,Liu Zhenyang
出处
期刊:Journal of Ethnopharmacology [Elsevier]
卷期号:319: 117027-117027
标识
DOI:10.1016/j.jep.2023.117027
摘要

Shang-Ke-Huang-Shui lotion (SKHS), an experiential formula based on the theory of traditional Chinese medicine as a hospital preparation, combines Coptidis Rhizoma, Phellodendri Chinensis Cortex, Gardeniae Fructus, Arnebiae Radix, Menthae Haplocalycis Herba and Alumen. While it has acquired positive effects on the treatment of soft tissue injuries, there is no systematic safety assessment in recent studies.The study aimed to investigate the acute and long-term toxicity in New Zealand White rabbits using topical administration of SKHS.In the acute toxicity study, rabbits were given topical administration of SKHS extract (2.775 g crude drug/mL) 3 times daily in normal and broken skin. In the long-term toxicity study, rabbits underwent topical administration of SKHS extract (1.390, 0.694, 0.139 g crude drug/mL) 1 time per day in normal and broken skin for 90 days. Their general behavior, body weight, food intake, biochemical and hematologic parameters, organ coefficients, and pathological morphology were analyzed.Mild skin irritation was observed in rabbits with normal or broken skin following acute exposure to the high dose of SKHS. Evidence of toxicity was not observed in the rabbits exposed to SKHS for an extended period. Although some parameters have been significant changes, they cannot be considered treatment-related because they have remained within normal limits.Topical administration of SKHS could be considered relatively safe and did not reveal any severe toxicity or side effects in this study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
青椒发布了新的文献求助10
1秒前
1秒前
1秒前
某某发布了新的文献求助80
2秒前
bxr发布了新的文献求助10
2秒前
Solarenergy完成签到,获得积分0
3秒前
所所应助WY呀采纳,获得10
3秒前
猪猪完成签到 ,获得积分10
4秒前
4秒前
亦屿森发布了新的文献求助10
4秒前
5秒前
fox2shj完成签到,获得积分10
5秒前
samskaras发布了新的文献求助10
5秒前
cassie完成签到,获得积分10
5秒前
运医瘦瘦花生完成签到,获得积分10
5秒前
YINLANRUI发布了新的文献求助10
6秒前
阿七发布了新的文献求助30
6秒前
科目三应助fujun采纳,获得10
6秒前
xinxinqi完成签到 ,获得积分10
7秒前
觉觉发布了新的文献求助10
8秒前
星河梦枕完成签到,获得积分10
8秒前
8秒前
9秒前
9秒前
9秒前
龙猫完成签到,获得积分10
10秒前
LYB吕发布了新的文献求助10
10秒前
10秒前
11秒前
11秒前
11秒前
汉堡包应助寒冷书竹采纳,获得10
12秒前
英姑应助YINLANRUI采纳,获得10
12秒前
珍珠爱学习完成签到,获得积分10
12秒前
我爱读文献完成签到,获得积分10
13秒前
13秒前
喜东东完成签到 ,获得积分10
13秒前
jiusisuantai发布了新的文献求助10
14秒前
14秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3249546
求助须知:如何正确求助?哪些是违规求助? 2892770
关于积分的说明 8273971
捐赠科研通 2561035
什么是DOI,文献DOI怎么找? 1389479
科研通“疑难数据库(出版商)”最低求助积分说明 651200
邀请新用户注册赠送积分活动 627962