已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Metagenomic Analysis Reveals Large‐Scale Disruptions of the Gut Microbiome in Parkinson's Disease

普氏粪杆菌 基因组 微生物群 帕金森病 生物 疾病 肠道微生物群 肠道菌群 生物信息学 医学 遗传学 内科学 免疫学 基因
作者
Avril Metcalfe‐Roach,Mihai Cirstea,Adam C. Yu,Hena R. Ramay,Olabisi Oluwabukola Coker,Seti Boroomand,Faezeh Kharazyan,Davide Martino,Laura K. Sycuro,Silke Appel‐Cresswell,B. Brett Finlay
出处
期刊:Movement Disorders [Wiley]
标识
DOI:10.1002/mds.29959
摘要

Abstract Background Parkinson's disease (PD) has been consistently linked to alterations within the gut microbiome. Objective Our goal was to identify microbial features associated with PD incidence and progression. Methods Metagenomic sequencing was used to characterize taxonomic and functional changes to the PD microbiome and to explore their relation to bacterial metabolites and disease progression. Motor and non‐motor symptoms were tracked using Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) and levodopa equivalent dose across ≤5 yearly study visits. Stool samples were collected at baseline for metagenomic sequencing (176 PD, 100 controls). Results PD‐derived stool samples had reduced intermicrobial connectivity and seven differentially abundant species compared to controls. A suite of bacterial functions differed between PD and controls, including depletion of carbohydrate degradation pathways and enrichment of ribosomal genes. Faecalibacterium prausnitzii ‐specific reads contributed significantly to more than half of all differentially abundant functional terms. A subset of disease‐associated functional terms correlated with faster progression of MDS‐UPDRS part IV and separated those with slow and fast progression with moderate accuracy within a random forest model (area under curve = 0.70). Most PD‐associated microbial trends were stronger in those with symmetric motor symptoms. Conclusion We provide further evidence that the PD microbiome is characterized by reduced intermicrobial communication and a shift to proteolytic metabolism in lieu of short‐chain fatty acid production, and suggest that these microbial alterations may be relevant to disease progression. We also describe how our results support the existence of gut‐first versus brain‐first PD subtypes. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
刚刚
刚刚
陈过年完成签到 ,获得积分10
刚刚
wanci应助奶昔采纳,获得10
1秒前
song完成签到,获得积分10
1秒前
Akim应助tjh采纳,获得10
2秒前
xia完成签到,获得积分10
3秒前
Singularity应助墨菲特采纳,获得10
4秒前
王一生完成签到,获得积分0
4秒前
song发布了新的文献求助10
4秒前
yu完成签到 ,获得积分10
6秒前
8秒前
halo完成签到 ,获得积分10
8秒前
9秒前
10秒前
白熊完成签到,获得积分10
10秒前
ruaruaburua发布了新的文献求助10
11秒前
踏实的傲白完成签到 ,获得积分10
12秒前
guozizi发布了新的文献求助10
13秒前
16秒前
生活的狗完成签到,获得积分10
17秒前
安内大大完成签到,获得积分20
19秒前
Akim应助自然的汉堡采纳,获得10
21秒前
ZhX发布了新的文献求助60
21秒前
安内大大发布了新的文献求助10
21秒前
李爱国应助小田采纳,获得10
22秒前
22秒前
22秒前
24秒前
鳗鱼冰薇完成签到 ,获得积分10
25秒前
25秒前
年轻的雁露完成签到,获得积分10
25秒前
皮老师发布了新的文献求助10
27秒前
桐桐应助mashichuang采纳,获得10
27秒前
28秒前
科研通AI5应助粉条采纳,获得10
28秒前
桑叶发布了新的文献求助10
29秒前
cAMP关注了科研通微信公众号
30秒前
leisure完成签到,获得积分20
31秒前
皮老师完成签到,获得积分10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976418
求助须知:如何正确求助?哪些是违规求助? 3520512
关于积分的说明 11203586
捐赠科研通 3257127
什么是DOI,文献DOI怎么找? 1798594
邀请新用户注册赠送积分活动 877804
科研通“疑难数据库(出版商)”最低求助积分说明 806523