化学
脂肪肝
脂肪酸
色谱法
生物化学
疾病
内科学
医学
作者
Zijia Zhang,Yawen Liu,Gaohan Li,Xiaoling Chen,Lei Min,Yang Zhou,Huali Long,Qinhua Chen,Jinjun Hou,Wanying Wu
标识
DOI:10.1016/j.chroma.2024.465406
摘要
The complex pathological mechanisms of non-alcoholic fatty liver disease (NAFLD) are closely related to dysregulated lipid metabolism, and the therapeutic effects of the traditional Chinese medicine Zexie-Baizhu Decoction (AA) on NAFLD have been gaining increasing attention. However, research into altered lipid metabolism, especially fatty acids, in NAFLD and the intervention of AA faces technical challenges, especially in the precise quantitative analysis of fatty acids in biological samples. The high complexity of biological matrices, particularly after drug intervention, greatly increases the difficulty of detection. Therefore, this study innovatively developed a simple and economical stable isotope derivatization technique by synthesizing d
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