化学
髓系白血病
白血病
癌症研究
药理学
内科学
医学
作者
Tian‐Hua Wei,Zixuan Wang,Meng‐Yi Lu,Yujing Xu,Jin Yang,Xing-Feng Ni,Cheng Yang,Mengyuan Zhang,Jia‐Chuan Liu,Qingqing Li,Jiao Cai,Zijun Chen,Ji-Bo Kang,Nan Li,Wei‐Chen Dai,Ning Ding,Yan‐Cheng Yu,Xuejiao Leng,Xin Xue,Xiao-Long Wang
标识
DOI：10.1021/acs.jmedchem.4c00529
摘要
The FLT3-ITD (internal tandem duplication) mutant has been a promising target for acute myeloid leukemia (AML) drug discovery but is now facing the challenge of resistance due to point mutations. Herein, we have discovered a type II FLT3 inhibitor,
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