Positive 68Ga-FAPI-04 PET/MRI and Negative 18F-FDG PET/CT Imaging in Incidental Appendiceal Goblet Cell Adenocarcinoma

Abstract A 70-year-old woman presented with left ovarian mass and thickened peritoneum. 18 F-FDG PET/CT showed no significant FDG-avid in the whole body. 68 Ga-FAPI-04 demonstrated abnormally high FAPI uptake in the ileocecal region, left ovarian lesion, and thickened peritoneum. The postoperative pathology confirmed the appendiceal goblet cell adenocarcinoma. This case highlights the superior and innovative diagnostic role of 68 Ga-FAPI-04 in appendiceal goblet cell adenocarcinoma and its metastases.