流式细胞术
免疫系统
医学
淋巴
肺癌
B细胞
免疫学
淋巴细胞
淋巴结
病理
内科学
抗体
作者
Agata Raniszewska,Iwona Kwiecień,Elżbieta Rutkowska,Joanna Bednarek,Rafał Sokołowski,Piotr Miklusz,Piotr Rzepecki,Karina Jahnz‐Różyk
出处
期刊:Cells
[Multidisciplinary Digital Publishing Institute]
日期:2024-07-29
卷期号:13 (15): 1274-1274
被引量:1
标识
DOI:10.3390/cells13151274
摘要
Although the role of T lymphocytes in sarcoidosis (SA) and lung cancer (LC) is quite well reported, the occurrence of B cells in disease microenvironments may suggest their potential role as natural modifiers of the immune response. The aim of this study was to investigate the B-cell profile and lymphocyte-related hematological parameters between patients with SA, LC and healthy controls (HCs). The cells were assessed by flow cytometry and a hematological analyzer in peripheral blood (PB) and material from lymph nodes (LNs) obtained by the EBUS/TBNA method. We showed that in SA patients, there were higher percentages of naïve B and CD21low B cells and a lower percentage of class-switched memory B cells than LC patients in LNs. We observed a higher median proportion of non-switched memory and transitional B cells in the PB of SA patients than in LC patients. We noticed the lowest median proportion of class-switched memory B cells in the PB from SA patients. LC patients had a higher percentage of RE-LYMP and AS-LYMP than SA patients. Our study presented a different profile of B-cell subpopulations in SA and LC patients, distinguishing dominant subpopulations, and showed the relocation from distant compartments of the circulation to the disease microenvironment, thus emphasizing their role.
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