神经退行性变
神经科学
疾病
痴呆
小胶质细胞
帕金森病
适应性
失调家庭
神经保护
神经炎症
医学
生物信息学
生物
炎症
免疫学
精神科
内科学
生态学
作者
Oliver Cooper,Penelope J. Hallett,Ole Isacson
出处
期刊:FEBS Journal
[Wiley]
日期:2022-09-27
卷期号:291 (4): 632-645
被引量:13
摘要
Brain health requires circuits, cells and molecular pathways to adapt when challenged and to promptly reset once the challenge has resolved. Neurodegeneration occurs when adaptability becomes confined, causing challenges to overwhelm neural circuitry. Studies of rare and common neurodegenerative diseases suggest that the accumulation of lipids can compromise circuit adaptability. Using microglia as an example, we review data that suggest increased lipid concentrations cause dysfunctional inflammatory responses to immune challenges, leading to Alzheimer's disease, Parkinson's disease and dementia. We highlight current approaches to treat lipid metabolic and clearance pathways and identify knowledge gaps towards restoring adaptive homeostasis in individuals who are at‐risk of losing cognition.
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