Firing pattern of fasciculations in ALS

束状 肌萎缩侧索硬化 耐火期 运动神经元 医学 肱二头肌 上运动神经元 神经科学 解剖 脊髓 心理学 心脏病学 内科学 疾病
作者
Bert U. Kleine,Dick F. Stegeman,Helenius J. Schelhaas,Machiel J. Zwarts
出处
期刊:Neurology [Ovid Technologies (Wolters Kluwer)]
卷期号:70 (5): 353-359 被引量:87
标识
DOI:10.1212/01.wnl.0000300559.14806.2a
摘要

In amyotrophic lateral sclerosis (ALS), the origin of fasciculations is disputed. We hypothesized that the discharge pattern of fasciculation potentials (FPs) would be different for FPs arising in the motor axon or in the spinal motor neuron.FPs were recorded by high-density surface EMG of the biceps brachii or vastus lateralis muscle for 15 minutes in 10 patients with ALS. Records were decomposed into different FP waveforms and their firing moments. Interspike interval (ISI) histograms were constructed for FPs that fired more than 100 times.Two types of ISI histograms were found. 1) In 23 of 30 different FPs with a total of 8,597 ISIs, the refractory period was 3 to 4 msec. ISIs longer than 15 msec had a Poisson distribution. Five of these 23 FPs discharged doublets with an ISI of approximately 5 msec, indicative of supernormality. This is consistent with the FPs arising in motor axons. 2) In the other 7 FPs, accounting for 11,266 ISIs, the refractory period was 17 to 46 msec. The preferred ISI duration was around 80 msec. Both timing factors are consistent with origin in the spinal motor neuron.Firing pattern analysis, based on high-density surface EMG, can detect fasciculation potentials (FPs) of axonal and neuronal origin in amyotrophic lateral sclerosis. The two FP types coexist within the same muscle. The recognition that clinically identical fasciculations conceal the existence of two types of FP that can be studied in a noninvasive manner will introduce a new aspect in the research of motor neuron disease.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
1秒前
ohm发布了新的文献求助10
1秒前
萧白竹发布了新的文献求助10
1秒前
vv完成签到 ,获得积分10
2秒前
orixero应助炙热念双采纳,获得10
2秒前
慈祥的金针菇完成签到,获得积分10
3秒前
cxm完成签到,获得积分10
3秒前
不配.应助xia采纳,获得10
5秒前
井野浮应助冷傲的薯片采纳,获得30
6秒前
6秒前
yyy发布了新的文献求助10
6秒前
单手开坦克完成签到,获得积分10
7秒前
7秒前
1609855535完成签到,获得积分10
7秒前
ss完成签到 ,获得积分10
8秒前
9秒前
9秒前
黄橙子发布了新的文献求助10
9秒前
federish完成签到 ,获得积分10
10秒前
粗犷的老虎完成签到,获得积分10
12秒前
难摧发布了新的文献求助10
12秒前
cctv18应助宝宝采纳,获得10
12秒前
852应助宝宝采纳,获得20
12秒前
Singularity应助zhouxu采纳,获得10
13秒前
13秒前
15秒前
喜悦鹭洋完成签到,获得积分10
15秒前
luyjabc完成签到,获得积分10
17秒前
17秒前
17秒前
深情安青应助李浩然采纳,获得10
18秒前
18秒前
20秒前
甜甜盼夏发布了新的文献求助10
20秒前
nine完成签到,获得积分10
20秒前
呵呵发布了新的文献求助10
20秒前
Avery发布了新的文献求助20
22秒前
科研通AI2S应助BWZ采纳,获得10
22秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 830
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3247867
求助须知:如何正确求助?哪些是违规求助? 2891062
关于积分的说明 8266031
捐赠科研通 2559319
什么是DOI,文献DOI怎么找? 1388095
科研通“疑难数据库(出版商)”最低求助积分说明 650694
邀请新用户注册赠送积分活动 627581