血脑屏障
抗体
医学
免疫学
神经科学
非人灵长类
中枢神经系统
双特异性抗体
生物
单克隆抗体
进化生物学
作者
Yang Yu,Jasvinder K. Atwal,Yin Zhang,Raymond K. Tong,Kristin R. Wildsmith,Christine Tan,Nga Bien‐Ly,Maria Hersom,Janice Maloney,William J. Meilandt,Daniela Bumbaca,Kapil Gadkar,Kwame Hoyte,Wilman Luk,Yanmei Lu,James A. Ernst,Kimberly Scearce‐Levie,Jessica A. Couch,Mark S. Dennis,Ryan J. Watts
标识
DOI：10.1126/scitranslmed.3009835
摘要
Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β-amyloid.
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