The biochemical basis of zinc physiology

articleThe biochemical basis of zinc physiologyB. L. Vallee, and K. H. FalchukB. L. ValleeDepartment of Medicine, Harvard Medical School, Boston,Massachusetts., andK. H. FalchukDepartment of Medicine, Harvard Medical School, Boston,Massachusetts.Published Online:01 Jan 1993https://doi.org/10.1152/physrev.1993.73.1.79MoreSectionsPDF (11 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAPS Cross-Journal Collections125th Anniversary Collection Cited ByRoles for endothelial zinc homeostasis in vascular physiology and coronary artery disease10 September 2018 | Critical Reviews in Food Science and Nutrition, Vol. 59, No. 21A Brief Overview from the Physiological and Detrimental Roles of Zinc Homeostasis via Zinc Transporters in the Heart8 August 2018 | Biological Trace Element Research, Vol. 188, No. 1A novel fluorescent sensor based on a diarylethene containing a hydrazinylpyridine unit for Cd2+ and Zn2+ with high selectivityJournal of Photochemistry and Photobiology A: Chemistry, Vol. 367A review of select minerals influencing the haematopoietic process9 July 2018 | Nutrition Research Reviews, Vol. 31, No. 2Zinc uptake promotes myoblast differentiation via Zip7 transporter and activation of Akt signalling transduction pathway11 September 2018 | Scientific Reports, Vol. 8, No. 1Zinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models22 August 2018 | Communications Biology, Vol. 1, No. 1Thiacalix[4]arenes Remove the Inhibitory Effects of Zn Cations on the Myosin ATPase Activity25 July 2018 | Nanoscale Research Letters, Vol. 13, No. 1Temperature effects on Zn-responses and Zn-reclamation capacity of two native Brazilian plant species: Implications of climate changeEnvironmental and Experimental Botany, Vol. 155A novel chromone and rhodamine derivative as fluorescent probe for the detection of Zn(II) and Al(III) based on two different mechanismsSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 204A reversible fluorescent chemosensor for the rapid detection of Hg2+ in an aqueous solution: Its logic gates behaviorSensors and Actuators B: Chemical, Vol. 273Cadmium exposure during pregnancy and lactation: materno-fetal and newborn repercussions of Cd( ii ), and Cd–metallothionein complexes1 January 2018 | Metallomics, Vol. 10, No. 10Effect of In Ovo Zinc Injection on the Embryonic Development and Epigenetics-Related Indices of Zinc-Deprived Broiler Breeder Eggs9 February 2018 | Biological Trace Element Research, Vol. 185, No. 2Fluoride Alters Serum Elemental (Calcium, Magnesium, Copper, and Zinc) Homeostasis Along with Erythrocyte Carbonic Anhydrase Activity in Fluorosis Endemic Villages and Restores on Supply of Safe Drinking Water in School-Going Children of Nalgonda District, India17 February 2018 | Biological Trace Element Research, Vol. 185, No. 2Single and combined effects of Zn, Mn and Fe on the Neotropical freshwater bivalve Anodontites trapesialis : Bioaccumulation and biochemical biomarkersEcotoxicology and Environmental Safety, Vol. 161Substituent effect on fluorescence signaling of the naphthalene carbohydrazone based chemosensor: Its implication in the detection of Zn(II) ions and secondary sensing PP iSensors and Actuators B: Chemical, Vol. 270Effects of methionine hydroxyl analog chelated zinc on laying performance, eggshell quality, eggshell mineral deposition, and activities of Zn-containing enzymes in aged laying hens1 June 2018 | Poultry Science, Vol. 97, No. 10Monoterpenoid derivative based ratiometric fluorescent chemosensor for bioimaging and intracellular detection of Zn2+ and Mg2+ ionsJournal of Photochemistry and Photobiology A: Chemistry, Vol. 364Improvement of symptoms in a rat model of depression through combined zinc and folic acid administration via up-regulation of the Trk B and NMDANeuroscience Letters, Vol. 683Highly Sensitive Fluorescence Imaging of Zn 2+ and Cu 2+ in Living Cells with Signal Amplification Based on Functional DNA Self-Assembly5 July 2018 | Analytical Chemistry, Vol. 90, No. 15Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets7 August 2018 | Frontiers in Neuroscience, Vol. 12Synthesis and characterization of phenoxo-bridged dinuclear zinc(II) halide complexes: Role of electron withdrawing group on phosphatase activity27 July 2018 | Journal of Chemical Sciences, Vol. 130, No. 8Intracellular imaging of zinc ion in living cells by fluorescein based organic nanoparticlesSensors and Actuators B: Chemical, Vol. 267Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls26 July 2018 | Nutrients, Vol. 10, No. 8Broad spectrum antimicrobial activity of Ca(Zn(OH)3)2·2H2O and ZnO nanoparticles synthesized by the sol–gel method31 July 2018 | Journal of Sol-Gel Science and Technology, Vol. 97Review of In Vitro Toxicity of Nanoparticles and Nanorods—Part 225 July 2018Insects as sources of iron and zinc in human nutrition23 July 2018 | Nutrition Research Reviews, Vol. 29Anti-σ factor YlaD regulates transcriptional activity of σ factor YlaC and sporulation via manganese-dependent redox-sensing molecular switch in Bacillus subtilis14 May 2018 | Biochemical Journal, Vol. 475, No. 13Nanofertilizer for Precision and Sustainable Agriculture: Current State and Future Perspectives23 August 2017 | Journal of Agricultural and Food Chemistry, Vol. 66, No. 26Flow of toxic metals in food-web components of tropical mangrove ecosystem, Southern India18 January 2018 | Human and Ecological Risk Assessment: An International Journal, Vol. 24, No. 5Seed priming with iron and zinc in bread wheat: effects in germination, mitosis and grain yield16 February 2018 | Protoplasma, Vol. 255, No. 4Effects of Zinc Oxide Nanoparticles on Performance, Egg Quality, Tissue Zinc Content, Bone Parameters, and Antioxidative Status in Laying Hens18 October 2017 | Biological Trace Element Research, Vol. 184, No. 1Transition Metal Sequestration by the Host-Defense Protein CalprotectinAnnual Review of Biochemistry, Vol. 87, No. 1Effects of Arsenic Compounds on Microminerals Content and Antioxidant Enzyme Activities in Rat Liver6 September 2017 | Biological Trace Element Research, Vol. 183, No. 2Application of dual cloud point extraction for the enrichment of zinc in serum samples of psychiatric patients prior to analysis by FAASJournal of Industrial and Engineering Chemistry, Vol. 62Global transcriptional regulation by BirA in enterohemorrhagic Escherichia coli O157:H7Future Microbiology, Vol. 13, No. 7Signaling pathways involved in human sperm hyperactivated motility stimulated by Zn 2+30 May 2018 | Molecular Reproduction and Development, Vol. 30Mineral Composition of Berberis aristata DC Roots10 July 2018 | Analytical Chemistry Letters, Vol. 8, No. 3CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis3 April 2018 | mBio, Vol. 9, No. 2Diaminomaleonitrile based chromo-fluorescent receptor molecule for selective sensing of Mn(II) and Zn(II) ionsSensors and Actuators B: Chemical, Vol. 260Dietary Zinc Intake and Its Association with Metabolic Syndrome Indicators among Chinese Adults: An Analysis of the China Nutritional Transition Cohort Survey 20157 May 2018 | Nutrients, Vol. 10, No. 5Exploring the Scope of Photo-Induced Electron Transfer–Chelation-Enhanced Fluorescence–Fluorescence Resonance Energy Transfer Processes for Recognition and Discrimination of Zn 2+ , Cd 2+ , Hg 2+ , and Al 3+ in a Ratiometric Manner: Application to Sea Fish Analysis16 April 2018 | ACS Omega, Vol. 3, No. 4Modulation of Nuclearity by Zn(II) and Cd(II) in Their Complexes with a Polytopic Mannich Base Ligand: A Turn-On Luminescence Sensor for Zn(II) and Detection of Nitroaromatic Explosives by Zn(II) Complexes10 March 2018 | Crystal Growth & Design, Vol. 18, No. 4Zinc regulates vascular endothelial cell activity through zinc-sensing receptor ZnR/GPR39Donghui Zhu, Yingchao Su, Yufeng Zheng, Bingmei Fu, Liping Tang, andYi-Xian Qin1 April 2018 | American Journal of Physiology-Cell Physiology, Vol. 314, No. 4Aminoquinoline-Salicylaldimine Dyads as Highly Selective Turn-On Fluorescent Sensors for Zinc (II) Ions30 March 2018 | ChemistrySelect, Vol. 3, No. 12Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children21 January 2018 | British Journal of Nutrition, Vol. 119, No. 6Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins30 January 2018 | Biochemistry, Vol. 57, No. 11PATHOPHYSIOLOGICAL A SPECTS OF OLIGOELEMENT SUPPLEMENTATION IN A THLETES15 March 2018 | Acta Medica Medianae, Vol. 57, No. 2Cardiac changes in apoptosis, inflammation, oxidative stress, and nitric oxide system induced by prenatal and postnatal zinc deficiency in male and female rats7 November 2016 | European Journal of Nutrition, Vol. 57, No. 2Metallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity5 June 2017 | Biological Trace Element Research, Vol. 182, No. 1A ratiometric probe based on coumarin-quinoline for highly selective and sensitive detection of Zn 2+ ions in living cellsJournal of Photochemistry and Photobiology A: Chemistry, Vol. 355Transient neonatal zinc deficiency in exclusively breastfed preterm infants16 November 2017 | Journal of Paediatrics and Child Health, Vol. 54, No. 3'Turn-on' fluorescent chemosensors based on naphthaldehyde-2-pyridinehydrazone compounds for the detection of zinc ion in water at neutral pH6 July 2017 | Luminescence, Vol. 33, No. 1Zinc Potentiates Lipopolysaccharide-induced Nitric Oxide Production in Cultured Primary Rat Astrocytes9 November 2017 | Neurochemical Research, Vol. 43, No. 2Detoxification and cellular stress responses of unionid mussels Unio tumidus from two cooling ponds to combined nano-ZnO and temperature stressChemosphere, Vol. 193Subversion of nutritional immunity by the pathogenic Neisseriae13 October 2017 | Pathogens and Disease, Vol. 76, No. 1The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease1 February 2018 | International Journal of Molecular Sciences, Vol. 19, No. 2In Vivo Biochemistry: Single-Cell Dynamics of Cyclic Di-GMP in Escherichia coli in Response to Zinc Overload2 November 2017 | Biochemistry, Vol. 57, No. 1Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Aging and Longevity4 October 2017Microelements and Their Role in Human Health11 January 2018Zinc Solubilizing Bacteria for Zinc Biofortification in Cereals: A Step Toward Sustainable Nutritional Security20 June 2018Synthesis and Characterization of a Novel Ligand and Spectroscopic Study of the Formation of its Complexes with Different Cations and Their Sensory Characteristics22 January 2018 | Journal of Applied Spectroscopy, Vol. 84, No. 6Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial CellsEBioMedicine, Vol. 272-(2′-Hydroxyphenyl)-benzothiazole (HBT)-terpyridine conjugate: A highly specific ICT based fluorescent probe for Zn2+ ions and its application in confocal cell imagingJournal of Photochemistry and Photobiology A: Chemistry, Vol. 351Reusable Schiff base functionalized silica as a multi-purpose nanoprobe for fluorogenic recognition, quantification and extraction of Zn2+ ionsSensors and Actuators B: Chemical, Vol. 254From sea squirts to squirrelfish: facultative trace element hyperaccumulation in animals1 January 2018 | Metallomics, Vol. 10, No. 6Influence of zinc on glycosaminoglycan neutralisation during coagulation1 January 2018 | Metallomics, Vol. 10, No. 9Examining the homeostatic distribution of metals and Zn isotopes in Göttingen minipigs1 January 2018 | Metallomics, Vol. 10, No. 9A multi-responsive thiosemicarbazone-based probe for detection and discrimination of group 12 metal ions and its application in logic gates1 January 2018 | New Journal of Chemistry, Vol. 42, No. 18A highly sensitive fluorescent probe for bioimaging zinc ion in living cells and zebrafish models1 January 2018 | New Journal of Chemistry, Vol. 42, No. 14Terpyridine derivatives as "turn-on" fluorescence chemosensors for the selective and sensitive detection of Zn 2+ ions in solution and in live cells1 January 2018 | Photochemical & Photobiological Sciences, Vol. 17, No. 8Effect of zinc concentration and source on performance, tissue mineral status, activity of superoxide dismutase enzyme and lipid peroxidation of meat in broiler chickensAnimal Production Science, Vol. 58, No. 10Associação das concentrações séricas de zinco com hipercolesterolemia e resistência à insulina em crianças brasileiras5 February 2018 | Cadernos de Saúde Pública, Vol. 34, No. 1Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease14 January 2018 | Nutrients, Vol. 10, No. 1Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrheaAnimal Nutrition, Vol. 3, No. 4Low zinc levels may contribute to gynecomastia in pubertyJournal of Trace Elements in Medicine and Biology, Vol. 44Properties of bacterial and archaeal branched-chain amino acid aminotransferases3 January 2018 | Biochemistry (Moscow), Vol. 82, No. 13Interaction between supplemental zinc oxide and zilpaterol hydrochloride on growth performance, carcass traits, and blood metabolites in feedlot steers1Journal of Animal Science, Vol. 95, No. 12Zinc as a Gatekeeper of Immune Function25 November 2017 | Nutrients, Vol. 9, No. 12Zinc in Cellular Regulation: The Nature and Significance of "Zinc Signals"31 October 2017 | International Journal of Molecular Sciences, Vol. 18, No. 11Impact of Labile Zinc on Heart Function: From Physiology to Pathophysiology12 November 2017 | International Journal of Molecular Sciences, Vol. 18, No. 11A new role for zinc in the brain6 October 2017 | eLife, Vol. 6Spectrofluorimetric determination of Zn 2+ ions in aqueous medium using 5-(4-flourophenyl)-quinolin-8-ol27 March 2018 | Journal of the Association of Arab Universities for Basic and Applied Sciences, Vol. 24, No. 1Interactive effects of supplemental Zn sulfate and ractopamine hydrochloride on growth performance, carcass traits, and plasma urea nitrogen in feedlot heifers1Journal of Animal Science, Vol. 95, No. 10Understanding the Contribution of Zinc Transporters in the Function of the Early Secretory Pathway19 October 2017 | International Journal of Molecular Sciences, Vol. 18, No. 10Flame atomic absorption determination of ultra-trace zinc in environmental samples after pre-concentration by solid phase extraction30 September 2017 | European Journal of Chemistry, Vol. 8, No. 3Trace elements in unconventional animals: A 40-year experienceJournal of Trace Elements in Medicine and Biology, Vol. 43Novel oligothiophene-based dual-mode chemosensor: "Naked-Eye" colorimetric recognition of Hg 2+ and sequential off-on fluorescence detection of Fe 3+ and Hg 2+ in aqueous media and its application in practical samplesSensors and Actuators B: Chemical, Vol. 248Hydrazine bridged coumarin-pyrimidine conjugate as a highly selective and sensitive Zn 2+ sensor: Spectroscopic unraveling of sensing mechanism with practical applicationSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 183The Linoleic Acid: Dihomo-γ-Linolenic Acid Ratio (LA:DGLA)—An Emerging Biomarker of Zn Status1 August 2017 | Nutrients, Vol. 9, No. 8Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity6 July 2017 | International Journal of Molecular Sciences, Vol. 18, No. 7Unravelling the Role of Metallothionein on Development, Reproduction and Detoxification in the Wall Lizard Podarcis sicula19 July 2017 | International Journal of Molecular Sciences, Vol. 18, No. 7Ratiometric fluorescent probe based on symmetric peptidyl receptor with picomolar affinity for Zn 2+ in aqueous solutionSensors and Actuators B: Chemical, Vol. 245A novel 3-Hydroxychromone fluorescence sensor for intracellular Zn 2+ and its application in the recognition of prostate cancer cellsSensors and Actuators B: Chemical, Vol. 245Zinc in Infection and Inflammation17 June 2017 | Nutrients, Vol. 9, No. 6The role of zinc deficiency-induced changes in the phospholipid-protein balance of blood serum in animal depression model by Raman, FTIR and UV–vis spectroscopyBiomedicine & Pharmacotherapy, Vol. 89A simple Schiff-base fluorescence probe for the simultaneous detection of Ga 3+ and Zn 2+Inorganica Chimica Acta, Vol. 461Structural biology of solute carrier (SLC) membrane transport proteins13 April 2018 | Molecular Membrane Biology, Vol. 34, No. 1-2Zinc supplementation of vitrification medium improves in vitro maturation and fertilization of oocytes derived from vitrified-warmed mouse ovariesCryobiology, Vol. 74Zinc Transporter 3 (ZnT3) in the Enteric Nervous System of the Porcine Ileum in Physiological Conditions and during Experimental Inflammation7 February 2017 | International Journal of Molecular Sciences, Vol. 18, No. 2Functional and structural studies of a Phospholipase A 2 -like protein complexed to zinc ions: Insights on its myotoxicity and inhibition mechanismBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1861, No. 1A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancerArchives of Biochemistry and Biophysics, Vol. 611A dual chemosensor: Colorimetric detection of Co 2+ and fluorometric detection of Zn 2+Journal of Luminescence, Vol. 179A new coumarin based dual functional chemosensor for colorimetric detection of Fe 3+ and fluorescence turn-on response of Zn 2+Sensors and Actuators B: Chemical, Vol. 236New zinc(II) complexes of the Non-steroidal Anti-Inflammatory Drug (indomethacin) and various nitrogen donor ligands. Synthesis, characterization and biological activityPolyhedron, Vol. 117A reversible luminescent quinoline based chemosensor for recognition of Zn 2+ ions in aqueous methanol medium and its logic gate behaviorJournal of Luminescence, Vol. 177A novel urea-derived fluorescent sensor for highly selective and sensitive detection of Fe 3+Tetrahedron Letters, Vol. 57, No. 30A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells25 April 2016 | International Journal of Molecular Medicine, Vol. 37, No. 6Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: a study of the effects of zinc deficiency during lactationAyako Hashimoto, Miki Nakagawa, Natsuki Tsujimura, Shiho Miyazaki, Kumiko Kizu, Tomoko Goto, Yusuke Komatsu, Ayu Matsunaga, Hitoshi Shirakawa, Hiroshi Narita, Taiho Kambe, andMichio Komai1 March 2016 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 310, No. 5A mitochondria-targeted ratiometric two-photon fluorescent probe for biological zinc ions detectionBiosensors and Bioelectronics, Vol. 77Parameters Influencing Zinc in Experimental Systems in Vivo and in Vitro21 March 2016 | Metals, Vol. 6, No. 3Investigating the influence of histidine residues on the metal ion binding ability of the wheat metallothionein γ-E c -1 domainJournal of Inorganic Biochemistry, Vol. 153Zinc in Early Life: A Key Element in the Fetus and Preterm Neonate11 December 2015 | Nutrients, Vol. 7, No. 12Zinc deficiency during in vitro maturation of porcine oocytes causes meiotic block and developmental failure27 July 2015 | Molecular Medicine Reports, Vol. 12, No. 4Long-term pathological consequences of prenatal infection: beyond brain disordersMarie A. Labouesse, Wolfgang Langhans, andUrs Meyer1 July 2015 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 309, No. 1The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and MetabolismTaiho Kambe, Tokuji Tsuji, Ayako Hashimoto, andNaoya Itsumura1 July 2015 | Physiological Reviews, Vol. 95, No. 3Development of an imprinted polymeric sensor with dual sensing property for trace level estimation of zinc and arginineMaterials Science and Engineering: C, Vol. 49Zinc supplementation for improving pregnancy and infant outcome2 February 2015 | Cochrane Database of Systematic Reviews, Vol. 31Fishy Business: Effect of Omega-3 Fatty Acids on Zinc Transporters and Free Zinc Availability in Human Neuronal Cells15 August 2014 | Nutrients, Vol. 6, No. 8Expression analysis of zinc transporters in resting and stimulated human peripheral blood mononuclear cells13 January 2014 | Biomedical Reports, Vol. 2, No. 2Low Blood Zinc, Iron, and Other Sociodemographic Factors Associated with Behavior Problems in Preschoolers27 January 2014 | Nutrients, Vol. 6, No. 2Morphological and functional effects on cardiac tissue induced by moderate zinc deficiency during prenatal and postnatal life in male and female ratsAnalia Lorena Tomat, Lorena Vanesa Juriol, María Natalia Gobetto, Luciana Cecilia Veiras, Facundo Mendes Garrido Abregú, Judith Zilberman, Héctor Fasoli, Rosana Elesgaray, María Ángeles Costa, andCristina Teresa Arranz1 December 2013 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 305, No. 11Impaired Calcium Entry into Cells Is Associated with Pathological Signs of Zinc Deficiency6 May 2013 | Advances in Nutrition, Vol. 4, No. 3The Role of Metallothionein in Oxidative Stress15 March 2013 | International Journal of Molecular Sciences, Vol. 14, No. 3Vitamine und SpurenelementeThe role of zinc in immunity and inflammationZinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life4 January 2013 | Advances in Nutrition, Vol. 4, No. 1Potentiometric Zinc Ion Sensor Based on Honeycomb-Like NiO Nanostructures9 November 2012 | Sensors, Vol. 12, No. 11The effect of cadmium on Aβ levels in APP/PS1 transgenic mice26 April 2012 | Experimental and Therapeutic Medicine, Vol. 4, No. 1Turning Up The Heat: Immune Brinksmanship In The Acute-phase ResponseThe Quarterly Review of Biology, Vol. 87, No. 1Adult Consequences of Neonatal and Fetal NutritionAccumulation of the Major Yolk Protein and Zinc in the Agametogenic Sea Urchin GonadThe Biological Bulletin, Vol. 221, No. 2Zinc Interactions with Brewing Yeast: Impact on Fermentation Performance5 February 2018 | Journal of the American Society of Brewing Chemists, Vol. 69, No. 4Challenge of Studies on the Development of New Zn Complexes to Treat Diabetes MellitusYAKUGAKU ZASSHI, Vol. 131, No. 68-Aminoquinoline Functionalized Silica Nanoparticles: A Fluorescent Nanosensor for Detection of Divalent Zinc in Aqueous and in Yeast Cell Suspension3 May 2011 | ACS Applied Materials & Interfaces, Vol. 3, No. 5pH-Dependent Toxicity of High Aspect Ratio ZnO Nanowires in Macrophages Due to Intracellular Dissolution15 October 2010 | ACS Nano, Vol. 4, No. 11Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapsesBrain Research, Vol. 1323The Essential Toxin: Impact of Zinc on Human Health26 March 2010 | International Journal of Environmental Research and Public Health, Vol. 7, No. 4Brushite-Forming Mg-, Zn- and Sr-Substituted Bone Cements for Clinical Applications18 January 2010 | Materials, Vol. 3, No. 1Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cellsJun Jun Zhang, Min Wu, Norberta W. Schoene, Wen-Hsing Cheng, Thomas T. Y. Wang, Ali A. Alshatwi, Mohammed Alsaif, andKai Y. Lei1 September 2009 | American Journal of Physiology-Cell Physiology, Vol. 297, No. 3Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster26 March 2009 | The FASEB Journal, Vol. 23, No. 8Moderate zinc restriction during fetal and postnatal growth of rats: effects on adult arterial blood pressure and kidneyAnalía Lorena Tomat, Felipe Inserra, Luciana Veiras, María Constanza Vallone, Ana María Balaszczuk, María Angeles Costa, andCristina Arranz1 August 2008 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 295, No. 2Functional Near-Infrared Fluorescent Probes11 February 2008 | Chemistry - An Asian Journal, Vol. 3, No. 3Zinc Supplementation in the Elderly Reduces Spontaneous Inflammatory Cytokine Release and Restores T Cell FunctionsRejuvenation Research, Vol. 11, No. 1Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-930 October 2007 | Journal of Leukocyte Biology, Vol. 83, No. 2Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactoneManesh Thomas, Alex Vidal, Syamal K. Bhattacharya, Robert A. Ahokas, Yao Sun, Ivan C. Gerling, andKarl T. Weber1 October 2007 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 293, No. 4Zinc Supplementation of Pregnant Rats with Adequate Zinc Nutriture Suppresses Immune Functions in Their OffspringThe Journal of Nutrition, Vol. 137, No. 4The Expression of Metallothioneins on Imprint Smears of Prostate Carcinoma: Correlation with Clinicopathologic Parameters and Tumor Proliferative Capacity29 January 2018 | Tumori Journal, Vol. 93, No. 2The Molecular Evolution of Pyridoxal-5′-Phosphate-Dependent Enzymes22 November 2006Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortexBrain Research, Vol. 1118, No. 1Regulation of the Saccharomyces cerevisiae EKI1 -encoded Ethanolamine Kinase by Zinc Depletion21 March 2006 | Journal of Biological Chemistry, Vol. 281, No. 19Use of a zinc fluorophore to measure labile pools of zinc in body fluids and cell-conditioned mediaBioTechniques, Vol. 40, No. 4Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR ratsX. Ke*, Q. Lei*, S. J. James, S. L. Kelleher, S. Melnyk, S. Jernigan, X. Yu, L. Wang, C. W. Callaway, G. Gill, G. M. Chan, K. H. Albertine, R. A. McKnight, andR. H. Lane13 March 2006 | Physiological Genomics, Vol. 25, No. 1p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expressionWeidong Wu, Robert A. Silbajoris, Young E. Whang, Lee M. Graves, Philip A. Bromberg, andJames M. Samet1 November 2005 | American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 289, No. 5Efficacy of zinc in young infants with acute watery diarrheaThe American Journal of Clinical Nutrition, Vol. 82, No. 3Long-term moderate zinc supplementation increases exchangeable zinc pool masses in late-middle-aged men: the Zenith StudyThe American Journal of Clinical Nutrition, Vol. 82, No. 1Zinc-regulating Proteins, ZnT-1, and Metallothionein I/II Are Present in Different Cell Populations in the Mouse Testis26 June 2016 | Journal of Histochemistry & Cytochemistry, Vol. 53, No. 7Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exerciseThe American Journal of Clinical Nutrition, Vol. 81, No. 5Extracellular Zinc Triggers ERK-dependent Activation of Na+/H+ Exchange in Colonocytes Mediated by the Zinc-sensing ReceptorJournal of Biological Chemistry, Vol. 279, No. 50Measurement of presynaptic zinc changes in hippocampal mossy fibersBrain Research, Vol. 1026, No. 1Exchangeable zinc ions transiently accumulate in a vesicular compartment in the yeast Saccharomyces cerevisiaeBiochemical and Biophysical Research Communications, Vol. 323, No. 1Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementationExperimental Gerontology, Vol. 39, No. 10Oxidative stress in viral hepatitis and AIDSExperimental and Molecular Pathology, Vol. 77, No. 2A Naphthalimide Fluorescent Sensor for Zn 2+ Based on Photo-induced Electron TransferChemistry Letters, Vol. 33, No. 10S-Nitroso compounds interfere with zinc probing by ZinquinAnalytical Biochemistry, Vol. 332, No. 1Optimum zinc supplementation level in Nile tilapia Oreochromis niloticus juveniles dietsAquaculture, Vol. 238, No. 1-4Development of a bioassay from isolated digestive gland cells of the cuttlefish Sepia officinalis L. (Mollusca Cephalopoda): effect of Cu, Zn and Ag on enzyme activities and cell viabilityJournal of Experimental Marine Biology and Ecology, Vol. 309, No. 1Altered expression of genes related to zinc homeostasis in early mouse embryos exposed to di-2-ethylhexyl phthalateToxicology Letters, Vol. 152, No. 1Zinc is both an intracellular and extracellular regulator of K ATP channel function10 August 2004 | The Journal of Physiology, Vol. 559, No. 1Vitamin and mineral status: effects on physical performanceNutrition, Vol. 20, No. 7-8Influence of Age, Sex, and Production Class on Liver Zinc Concentration in Calves25 June 2016 | Journal of Veterinary Diagnostic Investigation, Vol. 16, No. 4Zn 2+ Inhibits Glycine Transport by Glycine Transporter Subtype 1b18 March 2004 | Journal of Biological Chemistry, Vol. 279, No. 22Regulation of Phospholipid Synthesis in Saccharomyces cerevisiae by Zinc17 March 2004 | Journal of Biological Chemistry, Vol. 279, No. 21Randomized controlled trial of prenatal zinc supplementation and fet