超抗原
T细胞受体
CD8型
细胞毒性T细胞
MHC II级
MHC限制
生物
细胞生物学
T细胞
MHC I级
抗原
抗原提呈细胞
免疫学
主要组织相容性复合体
免疫系统
体外
遗传学
作者
Thomas Herrmann,H. Robson MacDonald
标识
DOI:10.1006/smim.1993.1005
摘要
Staphylococcal enterotoxins (SE) are superantigens that bind to MHC class II molecules and activate T lymphocytes via the T cell receptor (TCR) Vβ domain. By analogy with T cell responses to conventional peptide antigens, it might be predicted that CD4 (MHC class II restricted) cells would respond better to SE than CD8 (MHC class I restricted) cells. Here we summarize evidence that in fact CD8 cells respond as well as CD4 cells to SE both in vitro and in vivo. These findings emphasize the unique character of TCR-superantigen interactions.
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