化学
铱
分子间力
表面改性
催化作用
甲基
群(周期表)
药物化学
立体化学
高分子化学
有机化学
分子
物理化学
作者
Taek Kang,Youngchan Kim,Donggun Lee,Zhen Wang,Sukbok Chang
摘要
Reported herein is the iridium-catalyzed direct amidation of unactivated sp3 C–H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated methyl groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C–H functionalization.
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