The pathogenesis of acute lung injury and the treatment effect of mesenchymal stem cells

Acute lung injury and acute respiratory distress syndrome are characterized by acute, progressive dyspnea, refractory hypoxemia and bilateral pulmonary infiltrates.Stem cell is a type of cell with strong differentiation function, which can differentiate into various types of cells, such as endothelial cells, epithelial cells, adipocytes and chondrocytes.The therapeutic potential and safety of mesenchymal stem cells(MSCs) in regenerative therapy and immune regulation have become the research hotspot.A large number of studies have shown that MSC can be used to treat lung injury in many ways, but the specific mechanism is not clear.Therefore, the mechanism of acute lung injury and the therapeutic effects of marrow MSC in acute lung injury will be reviewed in this paper. Key words: Acute lung injury; Mesenchymal stem cell