化学
邻接
卡宾
催化作用
组合化学
继电器
四级碳
有机化学
对映选择合成
量子力学
物理
功率(物理)
作者
Kenji Ota,Kazunori Nagao,Hirohisa Ohmiya
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-04-27
卷期号:22 (10): 3922-3925
被引量:78
标识
DOI:10.1021/acs.orglett.0c01199
摘要
An NHC-catalyzed radical relay enabled the vicinal alkylacylation of alkenes using aldehydes and tertiary α-bromo esters as a versatile route to δ-keto esters bearing an all-carbon quaternary center at the position α to the ester. The protocol was applicable to the reaction of tertiary α-bromoamides to afford δ-keto amides. This protocol enabled the conversion of readily available starting materials to congested and functionalized δ-ketocarbonyls in a single step without using transition metals.
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