沙门氏菌
生物
镁
微生物学
免疫学
遗传学
化学
细菌
有机化学
作者
Olivier Cunrath,Dirk Bumann
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-11-22
卷期号:366 (6468): 995-999
被引量:113
标识
DOI:10.1126/science.aax7898
摘要
The pleiotropic host resistance factor SLC11A1 (NRAMP1) defends against diverse intracellular pathogens in mammals by yet-unknown mechanisms. We compared Salmonella infection of coisogenic mice with different SLC11A1 alleles. SLC11A1 reduced Salmonella replication and triggered up-regulation of uptake systems for divalent metal cations but no other stress responses. SLC11A1 modestly diminished iron availability and acutely restricted Salmonella access to magnesium. Growth of Salmonella cells in the presence of SLC11A1 was highly heterogeneous and inversely correlated with expression of the crucial magnesium transporter gene mgtB We observed superimposable single-cell patterns in mice lacking SLC11A1 when we restricted Salmonella access to magnesium by impairing its uptake. Together, these findings identify deprivation of the main group metal magnesium as the main resistance mechanism of SLC11A1 against Salmonella.
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