药物输送
脂蛋白
药品
药理学
化学
毒品携带者
细胞
生物相容性
医学
胆固醇
生物化学
有机化学
作者
Sara Busatto,Sierra A. Walker,Whisper Grayson,Anthony Pham,Ming Tian,Nicole Nesto,Jacqueline Barklund,Joy Wolfram
标识
DOI:10.1016/j.addr.2020.08.003
摘要
Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.
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