Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis

类风湿性关节炎 氧化脂质 内科学 化学 免疫学 医学 生物化学 基因
作者
Javier Rodríguez‐Carrio,Roxana Coras,Mercedes Alpéri,Patricia López,Catalina Ulloa,Francisco Javier Ballina‐García,Aaron M. Armando,Oswald Quehenberger,Mònica Gumà,Ana Suárez
出处
期刊:Arthritis & rheumatology [Wiley]
卷期号:73 (3): 401-413 被引量:14
标识
DOI:10.1002/art.41537
摘要

Eicosanoids modulate inflammation via complex networks involving different pathways and downstream mediators, including oxylipins. Although altered eicosanoids are linked to rheumatoid arthritis (RA), suggesting that metabolization is enhanced, the role of oxylipins in disease stratification remains unexplored. This study was undertaken to characterize oxylipin networks during the earliest stages of RA and evaluate their associations with clinical features and treatment outcomes.In total, 60 patients with early RA (according to the American College of Rheumatology/European League Against Rheumatism 2010 criteria), 11 individuals with clinically suspect arthralgia (CSA), and 28 healthy control subjects were recruited. Serum samples were collected at the time of onset. In the early RA group, 50 patients who had not been exposed to disease-modifying antirheumatic drug (DMARD) or glucocorticoid treatment at the time of recruitment were prospectively followed up at 6 and 12 months after having received conventional synthetic DMARDs. A total of 75 oxylipins, mostly derived from arachidonic, eicosapentanoic, and linoleic acids, were identified in the serum by liquid chromatography tandem mass spectrometry.Univariate analyses demonstrated differences in expression patterns of 14 oxylipins across the RA, CSA, and healthy control groups, with each exhibiting a different trajectory. Network analyses revealed a strong grouping pattern of oxylipins in RA patients, whereas in individuals with CSA, a fuzzy network of oxylipins with higher degree and closeness was found. Partial least-squares discriminant analyses yielded variable important projection scores of >1 for 22 oxylipins, which allowed the identification of 2 clusters. Cluster usage differed among the groups (P = 0.003), and showed associations with disease severity and low rates of remission at 6 and 12 months in RA patients who were initially treatment-naive. Pathway enrichment analyses revealed different precursors and pathways between the groups, highlighting the relevance of the arachidonic acid pathway in individuals with CSA and the lipooxygenase pathway in patients with early RA. In applying distinct oxylipin signatures, subsets of seropositive and seronegative RA could be identified.Oxylipin networks differ across stages during the earliest phases of RA. These distinct oxylipin networks could potentially elucidate pathways with clinical relevance for disease progression, clinical heterogeneity, and treatment response.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
美梦成真完成签到,获得积分10
刚刚
Gakay完成签到,获得积分10
刚刚
量子星尘发布了新的文献求助10
1秒前
szj完成签到,获得积分0
2秒前
旦皋完成签到,获得积分10
2秒前
赘婿应助花壳在逃野猪采纳,获得10
3秒前
卷卷完成签到,获得积分10
5秒前
JSY完成签到 ,获得积分20
5秒前
xyh完成签到,获得积分10
6秒前
小曾应助Florencia采纳,获得10
7秒前
神外王001完成签到 ,获得积分10
7秒前
12秒前
你是谁完成签到,获得积分10
13秒前
majf完成签到,获得积分10
14秒前
linhanwenzhou完成签到,获得积分10
14秒前
JSY关注了科研通微信公众号
14秒前
853225598完成签到,获得积分10
14秒前
798完成签到,获得积分10
15秒前
善学以致用应助董怼怼采纳,获得10
15秒前
妍儿完成签到,获得积分20
16秒前
隐形曼青应助高大的水壶采纳,获得10
16秒前
马哥二弟无敌完成签到 ,获得积分10
17秒前
18秒前
Florencia完成签到,获得积分10
18秒前
务实颜完成签到 ,获得积分10
18秒前
18秒前
amberzyc应助小远采纳,获得10
19秒前
19秒前
20秒前
20秒前
21秒前
21秒前
Rondab应助小猪采纳,获得30
21秒前
DLDL完成签到,获得积分10
21秒前
22秒前
沧海云完成签到 ,获得积分10
22秒前
发嗲的迎天完成签到 ,获得积分10
23秒前
hahaha发布了新的文献求助10
24秒前
小马甲应助zx0914采纳,获得10
24秒前
阳光保温杯完成签到 ,获得积分10
24秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029