生物力学
光折变性角膜切除术
眼科
弹性模量
板层(表面解剖学)
角膜刀
角膜
医学
解剖
材料科学
复合材料
角膜磨镶术
作者
Emilio A. Torres‐Netto,Farhad Hafezi,Bogdan Spiru,Francesca Gilardoni,Nikki Hafezi,José Álvaro Pereira Gomes,J. Bradley Randleman,Walter Sekundo,Sabine Kling
出处
期刊:Journal of Cataract and Refractive Surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2020-12-14
卷期号:47 (7): 927-932
被引量:10
标识
DOI:10.1097/j.jcrs.0000000000000543
摘要
Purpose: To compare the elastic modulus of thin corneal lamellas using 2D stress–strain extensometry in healthy ex vivo human corneal lamellas with or without the presence of Bowman layer. Setting: Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Switzerland; ELZA Institute, Dietikon, Switzerland; Department of Ophthalmology, Philipps University of Marburg, Germany. Design: Prospective experimental laboratory study. Methods: Healthy human corneas were stripped of Descemet membrane and the endothelium for Descemet membrane endothelial keratoplasty. After epithelium removal, corneas were divided into 2 groups. In Group 1, Bowman layer was ablated with an excimer laser (20 μm thick, 10 mm). In Group 2, Bowman layer was left intact. Then, a lamella was cut from the anterior cornea with an automated microkeratome. Elastic and viscoelastic material properties were analyzed by 2D stress–strain extensometry between 0.03 and 0.70 N. Results: Twenty-six human corneas were analyzed. The mean lamella thickness was 160 ± 37 μm in corneas with Bowman layer and 155 ± 22 μm in corneas without. No statistically significant differences between flaps with and without Bowman layer were observed in the tangential elastic modulus between 5% and 20% strain (11.5 ± 2.9 kPa vs 10.8 ± 3.7 kPa, P > .278). Conclusions: The presence or absence of Bowman layer did not reveal a measurable difference in corneal stiffness. This may indicate that the removal of Bowman layer during photorefractive keratectomy does not represent a disadvantage to corneal biomechanics.
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