医学
类风湿性关节炎
免疫学
斯达
巨细胞动脉炎
自身免疫
促炎细胞因子
关节炎
炎症
信号转导
疾病
血管炎
抗体
内科学
生物
车站3
生物化学
作者
Yvan Jamilloux,Thomas El Jammal,Lucine Vuitton,Mathieu Gerfaud‐Valentin,Sébastien Kerever,P. Sève
标识
DOI:10.1016/j.autrev.2019.102390
摘要
Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide array of cytokines. JAK inhibitors are increasingly used in the setting of inflammatory and autoimmune diseases. While the currently approved drugs are panJAK inhibitors, more selective small molecules are being developed and tested in various rheumatic disorders. In this extensive review, we present evidence- or hypothesis-based perspectives for these drugs in various rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus, giant cell arteritis, and autoinflammatory diseases.
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