弥漫性大B细胞淋巴瘤
癌症研究
淋巴瘤
Wnt信号通路
PI3K/AKT/mTOR通路
贾纳斯激酶
伊德里希
信号转导
医学
靶向治疗
生物
伊布替尼
免疫学
癌症
内科学
白血病
慢性淋巴细胞白血病
细胞生物学
作者
Feifei Sun,Xiaosheng Fang,Xin Wang
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2019-09-26
卷期号:19 (17): 2047-2059
被引量:8
标识
DOI:10.2174/1871520619666190925143216
摘要
Background: Diffuse Large B Cell Lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma which is heterogeneous both clinically and morphologically. Over the past decades, significant advances have been made in the understanding of the molecular genesis, leading to the identification of multiple pathways and molecules that can be targeted for clinical benefit. Objective: The current review aims to present a brief overview of signal pathways of DLBCL, which mainly focus on B-cell antigen Receptor (BCR), Nuclear Factor-κB (NF-κB), Phosphatidylinositol-3-Kinase (PI3K) – protein kinase B (Akt) – mammalian Target of Rapamycin (mTOR), Janus Kinase (JAK) – Signal Transducer and Activator (STAT), Wnt/β-catenin, and P53 pathways. Methods: Activation of signal pathways may contribute to the generation, development, chemotherapy sensitivity of DLBCL, and expression of pathway molecules is associated with the prognosis of DLBCL. Some agents targeting these pathways have been proved effective and relevant clinical trials are in progress. These agents used single or combined with chemotherapy/each other might raise the possibility of improving clinical outcomes in DLBCL. Conclusion: This review presents several signal pathways of DLBCL and targeted agents had a tendency to improve the curative effect, especially in high-risk or relapsed/refractory DLBCL.
科研通智能强力驱动
Strongly Powered by AbleSci AI