异环磷酰胺
药代动力学
脑脊液
代谢物
医学
药理学
氮芥
化疗
内科学
环磷酰胺
依托泊苷
作者
G.P. Kaijser,Jan de Kraker,A. Bult,W.J.M. Underberg,J. H. Beijnen
出处
期刊:PubMed
日期:1998-07-25
卷期号:18 (3B): 1941-9
被引量:19
摘要
The pharmacokinetics of ifosfamide and some metabolites in children was investigated. The patients received various doses of ifosfamide, mostly by continuous infusion, over several days. The penetration of ifosfamide and its metabolites into the cerebrospinal fluid was also studied in four cases. Ifosfamide and 4-hydroxyifosfamide pass the blood-brain barrier, reaching cerebrospinal fluid concentrations that are almost as high as plasma concentrations.
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