Effect of glycosaminoglycan polysulphate on the metabolism of cartilage ribonucleic acid.

The effect of glycosaminoglycan polysulphate (GAGPS, Arteparon) on the metabolism of cartilage ribonucleic acid (RNA), collagen, and proteoglycan was studied. GAGPS stimulated the synthesis of collagen and the both components of proteoglycan. The effect of GAGPS on RNA was compared with those of chondroitin sulphate and heparin. All three investigated substances enhanced the RNA synthesis, GAGPS, however, had a comparable effect in concentrations ten times smaller.