Early Elevated HMGB1 Level Predicting the Outcome in Exertional Heatstroke

中暑 医学 HMGB1 内科学 炎症 胃肠病学 全身炎症反应综合征 败血症
作者
Huasheng Tong,Yanhong Tang,Yi Chen,Jun-Ming Qiu,Qiang Wen,Lei Su
出处
期刊:Journal of Trauma-injury Infection and Critical Care [Lippincott Williams & Wilkins]
卷期号:71 (4): 808-814 被引量:33
标识
DOI:10.1097/ta.0b013e318220b957
摘要

Heatstroke is generally considered as a syndrome of hyperthermia associated with systemic inflammation leading to multiorgan dysfunction. High mobility group box-1 protein (HMGB1) has recently been identified as a late mediator of systemic inflammation inducing multiorgan dysfunction. Elevation of plasma HMGB1 in heatstroke has been observed in animals, but there is no data available about its changes in heatstroke patients. The objectives of this study are to observe the time course of plasma HMGB1 changes and assess its prognostic value in patients with exertional heatstroke.Blood samples were taken from the patients with exertional heatstroke. Plasma HMGB1 level was detected by the enzyme-linked immunosorbent assay. C-reactive protein level was measured using a fully automated IMMAGE Immunochemistry System. Secreted HMGB1 in the culture supernatant of peripheral blood monocyte was assessed by immunoblotting. Acute Physiology and Chronic Health Evaluation II score was evaluated within 24 hours of admission.HMGB1 released into circulation at early stage, with peak levels occurring within 6 hours to 13 hours postheatstroke. Plasma HMGB1 levels remained markedly elevated in the following 6 days postheatstroke when compared with healthy volunteers (p<0.005). Positive correlation (r=0.798, p<0.001) was found between Acute Physiology and Chronic Health Evaluation II score and HMGB1 level at admission. HMGB1 levels at admission between survivors and nonsurvivors were significantly different (p<0.001). Receiver operating curve analysis showed that at a level of 47 ng/mL, HMGB1 level at admission indicated lethality with 77.4% sensitivity and 84.2% specificity.HMGB1 level at admission is an indicator of the severity of illness and a useful mortality predictor in exertional heatstroke.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
刚刚
星辰大海应助大橙子采纳,获得10
9秒前
9秒前
七QI完成签到 ,获得积分10
10秒前
13秒前
褚香旋完成签到,获得积分10
13秒前
一只狗东西完成签到 ,获得积分10
15秒前
宇老师发布了新的文献求助10
16秒前
17秒前
qiqi发布了新的文献求助30
19秒前
大橙子发布了新的文献求助10
22秒前
wzhang完成签到,获得积分10
23秒前
ken131完成签到 ,获得积分10
26秒前
myl完成签到,获得积分10
27秒前
728完成签到,获得积分10
33秒前
xiaofeng5838完成签到,获得积分10
33秒前
ronnie完成签到,获得积分10
33秒前
36秒前
寒冷芷蕊完成签到,获得积分20
36秒前
36秒前
Jane完成签到,获得积分10
36秒前
一氧化二氢完成签到,获得积分10
42秒前
凡事发生必有利于我完成签到,获得积分10
43秒前
yihaiqin完成签到 ,获得积分10
47秒前
轩辕剑身完成签到,获得积分0
47秒前
coolkid完成签到 ,获得积分0
48秒前
你怎么那么美完成签到,获得积分10
48秒前
游艺完成签到 ,获得积分10
51秒前
冬月完成签到 ,获得积分10
51秒前
薛乎虚完成签到 ,获得积分10
52秒前
53秒前
大胖完成签到,获得积分10
53秒前
野火197完成签到,获得积分10
57秒前
58秒前
量子星尘发布了新的文献求助10
1分钟前
April完成签到,获得积分10
1分钟前
周舟完成签到 ,获得积分10
1分钟前
V_I_G完成签到 ,获得积分10
1分钟前
nick完成签到,获得积分10
1分钟前
高高高完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022