Samarium Drug Preparation Research and Application in Tumor Pathology

At present, the pain of bone metastasis of cancer is mainly relieved by radiotherapy, chemotherapy, hormone therapy and opioid analgesics in the medicine.External beam radiation therapy for local or regional metastases has a certain effect, but it also has some limitations.SM preparation in recent years' new anti-cancer drugs in preparation, pharmacology and toxicology, mutation, drug and clinical research, has a strong affinity for bone tissue after administration, can quickly enrich in bone exchange area.Pharmacological experiments showed that SM formulations in mice blood quickly eliminated; the growth area is mainly distributed in the matrix of bone, especially bone mineralization in the layer.The labeled compound and radiation imaging detection, drug distribution in vivo in animal bone injury and normal bone tissue distribution ratio is 17.The disorder of bone metabolism caused can effectively inhibit the metastatic cancer cells or other bone diseases, also inhibits bone exchange intensification factor on pain nerve stimulation, and thus plays therapy and analgesic effects.