前列腺癌
组织病理学
前列腺切除术
核医学
体素
医学
前列腺
离体
体内
接收机工作特性
正电子发射断层摄影术
放射科
病理
癌症
内科学
生物
生物技术
作者
Constantinos Zamboglou,Florian Schiller,Tobias Fechter,Gesche Wieser,Cordula A. Jilg,Alin Chirindel,Nasr Salman,Vanessa Drendel,Martin Werner,Michael Mix,Philipp T. Meyer,Anca‐Ligia Grosu
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2016-01-01
卷期号:6 (10): 1619-1628
被引量:90
摘要
Purpose:We performed a voxel-wise comparison of 68 Ga-HBED-CC-PSMA PET/CT with prostate histopathology to evaluate the performance of 68 Ga-HBED-CC-PSMA for the detection and delineation of primary prostate cancer (PCa).Methodology: Nine patients with histopathological proven primary PCa underwent 68 Ga-HBED-CC-PSMA PET/CT followed by radical prostatectomy.Resected prostates were scanned by ex-vivo CT in a special localizer and histopathologically prepared.Histopathological information was matched to ex-vivo CT.PCa volume (PCa-histo) and non-PCa tissue in the prostate (NPCa-histo) were processed to obtain a PCa-model, which was adjusted to PET-resolution (histo-PET).Each histo-PET was coregistered to in-vivo PSMA-PET/CT data.Results: Analysis of spatial overlap between histo-PET and PSMA PET revealed highly significant correlations (p < 10 -5 ) in nine patients and moderate to high coefficients of determination (R²) from 42 to 82 % with an average of 60 ± 14 % in eight patients (in one patient R 2 = 7 %).Mean SUVmean in PCa-histo and NPCa-histo was 5.6 ± 6.1 and 3.3 ± 2.5 (p = 0.012).Voxel-wise receiver-operating characteristic (ROC) analyses comparing the prediction by PSMA-PET with the non-smoothed tumor distribution from histopathology yielded an average area under the curve of 0.83 ± 0.12.Absolute and relative SUV (normalized to SUVmax) thresholds for achieving at least 90 % sensitivity were 3.19 ± 3.35 and 0.28 ± 0.09, respectively.Conclusions: Voxel-wise analyses revealed good correlations of 68 Ga-HBED-CC-PSMA PET/CT and histopathology in eight out of nine patients.Thus, PSMA-PET allows a reliable detection and delineation of PCa as basis for PET-guided focal therapies.
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