亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Vitamin D Improves Learning and Memory Impairment in Streptozotocin-Induced Diabetic Mice.

链脲佐菌素 糖尿病 医学 内科学 生理盐水 内分泌学 维生素E 维生素D与神经学 莫里斯水上航行任务 维生素 抗氧化剂 化学 海马体 生物化学
作者
Ali Akbar Moghadamnia,Saeid Hakiminia,Mahmoud Baradaran,Sohrab Kazemi,Manouchehr Ashrafpour
出处
期刊:PubMed 卷期号:18 (6): 362-6 被引量:17
链接
标识
摘要

Diabetes mellitus (DM) is associated with memory and learning deficits. Evidence has been provided that vitamin D is involved in brain function. The aim of the present study was to determine the potential effect of vitamin D on acquisition and retention of memory and learning in streptozotocin (STZ)-induced diabetic mice.Experiments were performed in four groups of mice (each group; n = 7). Male mice were induced to diabetes by single dose (60 mg/kg, i.p.) injection of freshly prepared STZ dissolved in cold normal saline. Treatment with vitamin D (5µg/kg daily, i.p. dissolved in tween80) was begun at three days after diabetes induction. Passive avoidance (PA) learning method was used four weeks later. Retrieval test was carried out 24 h after training.Our results demonstrate significant impairment in acquisition and retrieval processes of PA learning in STZ- induced diabetic mice. Treatment with vitamin D improved learning and memory compared to the control group, both in acquisition and retrieval stages and reversed learning deficits in diabetic mice. In acquisition test, there were significant differences in the initial latency among the DM+Vit. D treated and control groups (P < 0.05). There was a significant difference in step-through latency between diabetic group treated with vitamin D compared to diabetic non-treated groups (P < 0.05).It is possible that the effects of Vitamin D on cognitive deficits in STZ-induced diabetic mice could be mediated through calcium homeostasis modulation. These findings suggest a potential role for vitamin D in the treatment of diabetes-associated cognition deficits. The positive effect of vitamin D on the avoidance task may be attributed to its neuronal protective roles metabolic regulating roles of prolonged vitamin D administration.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
30秒前
44秒前
小马甲应助科研通管家采纳,获得10
1分钟前
1分钟前
1分钟前
192724836发布了新的文献求助10
1分钟前
1分钟前
Easypass完成签到 ,获得积分10
1分钟前
慕青应助dihaha采纳,获得10
1分钟前
烟花应助Leo采纳,获得10
1分钟前
dihaha完成签到,获得积分10
1分钟前
Herbs完成签到 ,获得积分10
1分钟前
FashionBoy应助dihaha采纳,获得10
1分钟前
zqq完成签到,获得积分0
2分钟前
脑洞疼应助十三采纳,获得10
2分钟前
192724836完成签到,获得积分20
2分钟前
小锤发布了新的文献求助10
2分钟前
含蓄的寄翠完成签到,获得积分10
2分钟前
科研通AI2S应助192724836采纳,获得10
2分钟前
tinyliiyong完成签到,获得积分10
2分钟前
2分钟前
sss完成签到 ,获得积分10
2分钟前
小锤完成签到 ,获得积分20
3分钟前
李爱国应助科研通管家采纳,获得10
3分钟前
3分钟前
3分钟前
彭于晏应助十三采纳,获得10
3分钟前
布同完成签到,获得积分10
3分钟前
3分钟前
林思完成签到,获得积分10
3分钟前
老王家的二姑娘完成签到 ,获得积分10
3分钟前
平常的长颈鹿完成签到,获得积分10
3分钟前
852应助平常的长颈鹿采纳,获得10
3分钟前
3分钟前
FashionBoy应助KSung采纳,获得10
3分钟前
4分钟前
小胖子发布了新的文献求助10
4分钟前
机灵自中发布了新的文献求助50
4分钟前
机灵自中完成签到,获得积分10
4分钟前
4分钟前
高分求助中
Sustainability in ’Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
The ACS Guide to Scholarly Communication 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3072598
求助须知:如何正确求助?哪些是违规求助? 2726326
关于积分的说明 7493683
捐赠科研通 2374098
什么是DOI,文献DOI怎么找? 1258887
科研通“疑难数据库(出版商)”最低求助积分说明 610394
版权声明 596983