泊洛沙姆
无定形磷酸钙
材料科学
体内
生物医学工程
原位
布洛芬
双膦酸盐
纳米颗粒
钙
核化学
牙科
化学
医学
药理学
纳米技术
有机化学
复合材料
生物技术
骨吸收
生物
内科学
共聚物
冶金
聚合物
作者
Amany Mostafa,Mohamed H. Zaazou,L.C. Chow,Azza A. Mahmoud,Dalia Y. Zaki,Mona Basha,Mohamed A. Abdel Hamid,Maram E. Khallaf,Nehal F. Sharaf,Tamer M. Hamdy
标识
DOI:10.1088/1748-6041/10/6/065006
摘要
Nonsurgical local treatment of a periapical lesion arising from trauma or bacterial infection is a promising innovative approach. The present study investigated the feasibility of developing injectable amorphous calcium phosphate nanoparticles (ACP NPs) and ACP NPs loaded with an anti-inflammatory drug; ibuprofen (IBU-ACP NPs) in the form of thermoreversible in situ gels to treat periapical lesions with the stimulation of bone formation. NPs were produced by a spray-drying technique. Different formulations of Poloxamer 407 were incorporated with/without the produced NPs to form injectable gels. A drug release study was carried out. A 3 month in vivo test on a dog model also was assessed. Results showed successful incorporation of the drug into the NPs of CP during spray drying. The particles had mean diameters varying from 100 to 200 nm with a narrow distribution. A drug release study demonstrated controlled IBU release from IBU-ACP NPs at a pH of 7.4 over 24 h. The gelation temperature of the injectable in situ gels based on Poloxamer 407 was measured to be 30 °C. After 3 months of implantation in dogs, the results clearly demonstrated that the inclusion of ACP NPs loaded with IBU showed high degrees of periapical bone healing and cementum layer deposition around the apical root tip.
科研通智能强力驱动
Strongly Powered by AbleSci AI