结垢
安培法
氧化还原
化学
血清素
拉曼光谱
原电池
介电谱
神经递质
电极
材料科学
电化学
无机化学
膜
生物化学
物理
光学
物理化学
受体
有机化学
作者
Fenghui Zhu,Yifei Xue,Wenliang Ji,Xin Li,Wenjie Ma,Ping Yu,Ying Jiang,Lanqun Mao
标识
DOI:10.1002/anie.202212458
摘要
Abstract Serotonin (5‐HT) is a major neurotransmitter broadly involved in many aspects of feeling and behavior. Although its electro‐activity makes it a promising candidate for electrochemical sensing, the persistent generation of fouling layers on the electrode by its oxidation products presents a hurdle for reliable sensing. Here, we present a fouling‐free 5‐HT sensor based on galvanic redox potentiometry. The sensor efficiently minimizes electrode fouling as revealed by in situ Raman spectroscopy, ensuring a less than 3 % signal change in a 2 hour continuous experiment, whereas amperometric sensors losing 90 % within 30 min. Most importantly, the sensor is highly amenable for in vivo studies, permitting real‐time 5‐HT monitoring, and supporting the mechanism associated with serotonin release in brain. Our system offers an effective way for sensing different neurochemicals having significant fouling issues, thus facilitating the molecular‐level understanding of brain function.
科研通智能强力驱动
Strongly Powered by AbleSci AI