医学
人类健康
食品添加剂
食品安全
食品药品监督管理局
毒理
环境卫生
生物技术
食品科学
病理
生物
作者
Sharifa Sultana,Md. Mominur Rahman,Farjana Islam Aovi,Farhana Israt Jahan,Md Sakhawat Hossain,Shadia Afrin Brishti,Md. Yamin,Muniruddin Ahmed,Abdur Rauf,Rohit Sharma
标识
DOI:10.2174/1568026623666230117122433
摘要
Food color additives are used to make food more appetizing. The United States Food and Drug Administration (FDA) permitted nine artificial colorings in foods, drugs, and cosmetics, whereas the European Union (EU) approved five artificial colors (E-104, 122, 124, 131, and 142) for food. However, these synthetic coloring materials raise various health hazards. The present review aimed to summarize the toxic effects of these coloring food additives on the brain, liver, kidney, lungs, urinary bladder, and thyroid gland. In this respect, we aimed to highlight the scientific evidence and the crucial need to assess potential health hazards of all colors used in food on human and nonhuman biota for better scrutiny. Blue 1 causes kidney tumor in mice, and there is evidence of death due to ingestion through a feeding tube. Blue 2 and Citrus Red 2 cause brain and urinary bladder tumors, respectively, whereas other coloring additives may cause different types of cancers and numerous adverse health effects. In light of this, this review focuses on the different possible adverse health effects caused by these food coloring additives, and possible ways to mitigate or avoid the damage they may cause. We hope that the data collected from in vitro or in vivo studies and from clinical investigations related to the possible health hazards of food color additives will be helpful to both researchers and the food industry in the future.
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