Multiple xenoestrogen air pollutants and breast cancer risk: Statistical approaches to investigate combined exposures effect

异种雌激素 乳腺癌 污染物 空气污染物 环境卫生 环境科学 空气污染 风险评估 癌症 医学 环境化学 统计 内科学 化学 生物 数学 计算机科学 雌激素受体 生态学 计算机安全
作者
Amina Amadou,Camille Giampiccolo,Fabiola Bibi Ngaleu,Delphine Praud,Thomas Coudon,Lény Grassot,Élodie Faure,Florian Couvidat,Pauline Frenoy,Gianluca Severi,Francesca Romana Mancini,Pascal Roy,Béatrice Fervers
出处
期刊:Environmental Pollution [Elsevier BV]
卷期号:351: 124043-124043 被引量:1
标识
DOI:10.1016/j.envpol.2024.124043
摘要

Studies suggested that exposure to air pollutants, with endocrine disrupting (ED) properties, have a key role in breast cancer (BC) development. Although the population is exposed simultaneously to a mixture of multiple pollutants and ED pollutants may act via common biological mechanisms leading to synergic effects, epidemiological studies generally evaluate the effect of each pollutant separately. We aimed to assess the complex effect of exposure to a mixture of four xenoestrogen air pollutants (benzo-[a]-pyrene (BaP), cadmium, dioxin (2,3,7,8-Tétrachlorodibenzo-p-dioxin TCDD)), and polychlorinated biphenyl 153 (PCB153)) on the risk of BC, using three recent statistical methods, namely weighted quantile sum (WQS), quantile g-computation (QGC) and Bayesian kernel machine regression (BKMR). The study was conducted on 5,222 cases and 5,222 matched controls nested within the French prospective E3N cohort initiated in 1990. Annual average exposure estimates to the pollutants were assessed using a chemistry transport model, at the participants' residence address between 1990 and 2011. We found a positive association between the WQS index of the joint effect and the risk of overall BC (adjusted odds ratio (OR) = 1.10, 95% confidence intervals (CI): 1.03-1.19). Similar results were found for QGC (OR = 1.11, 95%CI: 1.03-1.19). Despite the association did not reach statistical significance in the BKMR model, we observed an increasing trend between the joint effect of the four pollutants and the risk of BC, when fixing other chemicals at their median concentrations. BaP, cadmium and PCB153 also showed positive trends in the multi-pollutant mixture, while dioxin showed a modest inverse trend. Despite we found a clear evidence of a positive association between the joint exposure to pollutants and BC risk only from WQS and QGC regression, we observed a similar suggestive trend using BKMR. This study makes a major contribution to the understanding of the joint effects of air pollution.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丁玲玲完成签到 ,获得积分10
1秒前
3秒前
zombleq完成签到 ,获得积分10
4秒前
牛马完成签到,获得积分10
4秒前
萧萧发布了新的文献求助30
9秒前
16秒前
c123完成签到 ,获得积分10
16秒前
文与武完成签到 ,获得积分10
18秒前
18秒前
1993963发布了新的文献求助10
22秒前
kk2024应助科研通管家采纳,获得20
25秒前
Ava应助科研通管家采纳,获得10
25秒前
科研通AI2S应助科研通管家采纳,获得10
25秒前
喝酸奶不舔盖完成签到 ,获得积分10
33秒前
热心的飞风完成签到 ,获得积分10
47秒前
海英完成签到,获得积分10
47秒前
bellapp完成签到 ,获得积分10
47秒前
顺顺利利毕业完成签到 ,获得积分10
50秒前
虚拟的水之完成签到 ,获得积分10
52秒前
科研通AI2S应助U9A采纳,获得10
54秒前
丘比特应助晨许沫光采纳,获得10
55秒前
心想事成完成签到 ,获得积分10
56秒前
flyingpig完成签到,获得积分10
58秒前
秋纳瑞完成签到 ,获得积分10
1分钟前
master-f完成签到 ,获得积分10
1分钟前
1分钟前
挪威的森林完成签到,获得积分10
1分钟前
隐形的非笑完成签到 ,获得积分10
1分钟前
科研通AI5应助大力听芹采纳,获得10
1分钟前
悠雯完成签到 ,获得积分10
1分钟前
传奇3应助Emily采纳,获得10
1分钟前
三脸茫然完成签到 ,获得积分10
1分钟前
1分钟前
端庄半凡完成签到 ,获得积分10
1分钟前
1分钟前
song完成签到 ,获得积分10
1分钟前
1分钟前
spring完成签到,获得积分10
1分钟前
Emily发布了新的文献求助10
1分钟前
贰鸟应助悠雯采纳,获得10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968559
求助须知:如何正确求助?哪些是违规求助? 3513358
关于积分的说明 11167368
捐赠科研通 3248732
什么是DOI,文献DOI怎么找? 1794465
邀请新用户注册赠送积分活动 875065
科研通“疑难数据库(出版商)”最低求助积分说明 804664