Gold-Catalyzed Alkoxy-Carbonylation of Organohalides

Herein, for the first time, we disclose the gold-catalyzed alkoxy-carbonylation of organohalides utilizing ligand-enabled Au(I)/Au(III) redox catalysis. The present methodology is found to be general, efficient, employs mild reaction conditions and showcases a broad substrate scope even with structurally complex molecules. Density functional theory (DFT) calculations revealed unique mechanistic pathways, distinct from those of conventional transition metal-catalyzed carbonylation reactions.