Notch信号通路
生物
细胞生物学
血管生成
壁细胞
萌芽血管生成
内皮干细胞
表型
血管平滑肌
信号转导
新生血管
癌症研究
遗传学
内分泌学
平滑肌
体外
基因
作者
Henar Cuervo,Severin Mühleder,Irene García-González,Rui Benedito
标识
DOI:10.1016/j.ceb.2023.102254
摘要
Vessel formation and differentiation to a proper hierarchical vasculature requires a coordinated effort from endothelial and mural cells. Over the last decade Notch was identified as a key player in this process by promoting vascular arterialization and modulating endothelial tip-stalk phenotypes. Recent work has identified that Notch fine-tunes the diverse endothelial phenotypes through regulation of canonical cell-cycle and metabolism regulators, such as ERK and Myc. During arterialization, Notch signaling inhibits the cell-cycle and metabolism of endothelial cells which coincides with the acquisition of arterial identity. During angiogenesis, the same molecular machinery prevents the hypermitogenic arrest and excessive sprouting of vessels. Notch also signals in pericytes and smooth muscle cells promoting vascular coverage and maturation. Here, we will review the latest findings on how Notch signals regulate the differentiation and interactions among vascular cells during organ development and homeostasis.
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