神经炎症
神经科学
疾病
机制(生物学)
自噬
发病机制
痴呆
生物
环状RNA
医学
阿尔茨海默病
生物信息学
细胞凋亡
小RNA
病理
基因
免疫学
遗传学
哲学
认识论
作者
Zulalai Abuduwaili,Yingao Fan,Wenyuan Tao,Yanting Chen,Yun Xu,Xiao‐Lei Zhu
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2024-10-24
卷期号:23
标识
DOI:10.2174/011570159x337659241014140824
摘要
Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease leading to dementia in the elderly, and the mechanisms of AD have not been fully defined. Circular RNAs (circRNAs), covalently closed RNAs produced by reverse splicing, have critical effects in the pathogenesis of AD. CircRNAs participate in production and clearance of Aβ and tau, regulate neuroinflammation, synaptic plasticity and the process of apoptosis and autophagy, indicating that circRNAs may be alternative biomarkers and therapeutic targets. Our review summarizes the functions of circRNAs in the progression and development of AD, which provide insights into the prospect of circRNAs in the diagnosis and treatment of AD.
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