粘液样脂肪肉瘤
第1周
脆弱性（计算）
肉瘤
脂肪肉瘤
癌症研究
生物
医学
计算生物学
病理
癌症
细胞周期
计算机科学
遗传学
计算机安全
细胞周期蛋白依赖激酶1
作者
Lorena Heinst,Kwang Seok Lee,Ruth Berthold,Ilka Isfort,Svenja Wosnig,Anna Kuntze,Susanne Häfner,Bianca Altvater,Claudia Rössig,Pierre Åman,Eva Wardelmann,Claudia Scholl,Wolfgang Hartmann,Stefan Fröhling,Marcel Trautmann
标识
DOI：10.1158/1078-0432.ccr-24-1152
摘要
The pathognomonic FUS::DDIT3 fusion protein drives myxoid liposarcoma (MLS) tumorigenesis via aberrant transcriptional activation of oncogenic signaling. Since FUS::DDIT3 has so far not been pharmacologically tractable to selectively target MLS cells, this study investigated the functional role of the cell cycle regulator WEE1 as novel FUS::DDIT3‑dependent therapeutic vulnerability in MLS.
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