Embolization of the Pancreas Using Microspheres: A Proof-of-Safety Study in a Porcine Model

医学 栓塞 胰腺 微球 概念证明 放射科 内科学 计算机科学 工程类 化学工程 操作系统
作者
B. Cline,Robert Meyerhoff,Jeffrey I. Everitt,Charles Kim
出处
期刊:Journal of Vascular and Interventional Radiology [Elsevier]
卷期号:35 (10): 1544-1550
标识
DOI:10.1016/j.jvir.2024.06.034
摘要

PurposeTo evaluate safety and impact of particle embolization on pancreatic function in a pig model.Materials and MethodsEmbolization of the dorsal pancreatic artery using 100–300-μm particles was performed on 14 Yorkshire pigs. Baseline and post-embolization glucose tolerance testing results and serum amylase/lipase levels were obtained. Pigs were observed for 2 weeks to assess for behavioral signs of pain/distress, bowel changes, and changes to intake/output. After 2 weeks, euthanasia and necropsy with gross and histopathologic assessment of the pancreas were performed.ResultsEmbolization was technically successful in all pigs. All animals survived the 2-week follow-up without evidence of pain/distress. There were significant increases in amylase and lipase at 24 and 48 hours (P < .001), which normalized by 2 weeks. There was minimal change in glucose tolerance testing at 2 weeks. Bowel habits were unchanged without diarrhea. At necropsy, all examined pancreases had fibrosis in the distal body and tail, without gross evidence of ongoing inflammation. On histopathologic evaluation, all pancreases demonstrated fibrosis in the embolized portions without evidence of active inflammation in treated or adjacent pancreatic tissue.ConclusionsParticle embolization of the pancreas was feasible and tolerated by all tested pigs with transient amylasemia, lipasemia, and mildly impaired glucose tolerance but without clinical or histopathologic evidence of acute pancreatitis and no evident impact on pancreatic endocrine or exocrine function.Graphical abstract

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