替莫唑胺
多孔硅
材料科学
胶质母细胞瘤
纳米颗粒
药代动力学
硅
纳米技术
生物医学工程
癌症研究
医学
药理学
光电子学
作者
Sera Shin,Hyejung Jo,Tomoyo Agura,Seoyoun Jeong,Hyo-Seop Ahn,Ye‐Jin Kim,Jae Seung Kang
摘要
Glioblastoma (GBM) is one of the most common and fatal primary brain tumors, with a 5-year survival rate of 7.2%. The standard treatment for GBM involves surgical resection followed by chemoradiotherapy, and temozolomide (TMZ) is currently the only approved chemotherapeutic agent for the treatment of GBM. However, hydrolytic instability and insufficient drug accumulation are major challenges that limit the effectiveness of TMZ chemotherapy. To overcome these limitations, we have developed a drug delivery platform utilizing porous silicon nanoparticles (pSiNPs) to improve the stability and blood-brain barrier penetration of TMZ. The pSiNPs are synthesized
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