氯硝柳胺
重新调整用途
药物重新定位
药品
药理学
抗菌活性
传统医学
化学
医学
生物
细菌
生态学
遗传学
作者
Fei Liu,Xiaofang Liang,Yu Zhang,Wangjun Deng,Wei Wang,Zhangping Lu,Qianqian Liu,Lianhua Wei
摘要
The development of antibiotic resistance complicates the treatment of infectious diseases and is a global public health threat. However, drug repurposing can address this resistance issue and reduce research and development costs. Niclosamide is a salicylanilide compound approved by the Food and Drug Administration (FDA), and it has been used clinically for treating parasitic infections for many years. Recent studies have shown that niclosamide can inhibit bacterial and fungus activity by affecting the quorum sensing system, biofilm formation, cell membrane potential, and other mechanisms. Here, we discuss recent advances in the antimicrobial applications of niclosamide and its derivatives to provide new perspectives in treating infectious diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI